SAB4200698
Anti-MR-Pro ADM antibody, Mouse monoclonal
clone 2E12E6, purified from hybridoma cell culture
别名:
Midregional proadrenomedullin
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关于此项目
NACRES:
NA.41
UNSPSC Code:
51111800
Clone:
2E12E6, monoclonal
Species reactivity:
human
Application:
ELISA (i)
Citations:
5
biological source
mouse
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
2E12E6, monoclonal
form
buffered aqueous solution
mol wt
antigen 5 kDa
species reactivity
human
concentration
~1 mg/mL
technique(s)
immunoblotting: 0.25-0.5 μg/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92)., indirect ELISA: 30-60 ng/mL using human recombinant peptide of MR-Pro ADM (amino acid 45-92) for coating.
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ADM (133)
General description
Monoclonal Anti-MR-Pro ADM (mid-regional pro adrenomedullin) (mouse IgG1 isotype) is derived from the hybridoma 2E12E6 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with human recombinant protein. Mid-regional pro-adrenomedullin (MR-proADM) is obtained as a by-product of post-translational processing of prepro adrenomedullin (Adm, AM) peptide. This gene is located on human chromosome 11p15.
Immunogen
human MR-Pro ADM recombinant protein.
Application
Anti-MR-pro ADM has been used in immunoblotting (~5 kDa) and indirect enzyme-linked immunosorbent assay (ELISA).
Biochem/physiol Actions
Mid-regional pro-adrenomedullin (MR-proADM) has been suggested as a biomarker for plasma concentrations of adrenomedullin as it is stoichiometrically generated and relatively stable in the plasma. Upregulated levels of MR-pro ADM were associated with an increased risk of mortality and morbidity in patients with heart failure, independent of natriuretic peptides. It can stimulate vascular endothelial barrier function.
Physical form
a solution in 0.01 M phosphate buffered saline pH 7.4, containing 15 mM sodium azide
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Adrenomedullin surges are linked to acute episodes of the systemic capillary leak syndrome (Clarkson disease)
Xie Z, et al.
Journal of Leukocyte Biology, 103(4), 749-759 (2018)
Mihael Potocki et al.
Current heart failure reports, 9(3), 244-251 (2012-06-27)
Circulating biomarkers have become increasingly important in diagnosing and risk-stratifying patients with heart failure (HF). While the natriuretic peptides have received much focus in the past decade, there is increasing interest in the role of other circulating biomarkers such as
Elevated levels of adrenomedullin in eutopic endometrium and plasma from women with endometriosis
Matson BC, et al.
Fertility and Sterility, 109(6), 1072-1078 (2018)
Mid-Regional Pro-Adrenomedullin (MR-proADM) as a Biomarker for Sepsis and Septic Shock: Narrative Review
Healthcare (Basel, Switzerland) , 6(3), 110-110 (2018)
Sex-specific effects of NLRP6/AVR and ADM loci on susceptibility to essential hypertension in a Sardinian population
Glorioso N, et al.
PLoS ONE, 8(10), e77562-e77562 (2013)
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