SAB4300282
Anti-phospho-SYK (pTyr323) antibody produced in rabbit
affinity isolated antibody
别名:
Anti-DKFZp313N1010 antibody produced in rabbit, Anti-FLJ25043 antibody produced in rabbit, Anti-FLJ37489 antibody produced in rabbit, Anti-spleen tyrosine kinase antibody produced in rabbit
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关于此项目
NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF, IHC (p), WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~72 kDa
species reactivity
human, rat, mouse
concentration
1 mg/mL
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:100, indirect immunofluorescence: 1:100-1:200, western blot: 1:500-1:1000
isotype
IgG
immunogen sequence
(N-P-YP-E-P)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr323)
Quality Level
Gene Information
human ... SYK(6850)
General description
Spleen tyrosine kinase (SYK) is a member of the non-receptor tyrosine kinase family. It is usually expressed in epithelial breast tissues and hematopoietic cells. The gene encoding it is localized on human chromosome 9q22.
Immunogen
Peptide sequence around phosphorylation site of tyrosine 323 (N-P-Y(p)-E- P), according to the protein SYK.
Biochem/physiol Actions
Spleen tyrosine kinase (SYK) is a tumor suppressor gene that helps to prevent the development and metastasis of breast cancer cells. It participates in B-cell receptor signaling. The protein helps to phosphorylate the α-tubulin subunits of microtubules. SYK aids in the coupling of receptors for antigen-antibody complexes. It also modulates cell proliferation and differentiation.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Novel SYK gene variations and changes in binding sites of miRs in breast cancer patients.
Faryal R
Cancer Biomarkers : Section A of Disease Markers (2016)
Inhibition of Spleen Tyrosine Kinase Potentiates Paclitaxel-Induced Cytotoxicity in Ovarian Cancer Cells by Stabilizing Microtubules.
Yu Y
Cancer Cell (2015)
Syk: a new player in the field of breast cancer
Zoe A
Breast Cancer Research (2000)
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.
Krisenko MO
The Journal of Biological Chemistry (2015)
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