SAB4300370
ANTI-TAU (MAPT) Antibody
rabbit polyclonal
别名:
Anti-DDPAC antibody produced in rabbit, Anti-FLJ31424 antibody produced in rabbit, Anti-FTDP-17 antibody produced in rabbit, Anti-MAPTL antibody produced in rabbit, Anti-microtubule-associated protein tau antibody produced in rabbit
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关于此项目
UNSPSC Code:
12352203
NACRES:
NA.41
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IF
Citations:
3
产品名称
Anti-MAPT (Ab-356) antibody produced in rabbit, affinity isolated antibody
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
~48 kDa, ~62 kDa, ~78 kDa
species reactivity
human, mouse, rat
concentration
1 mg/mL
technique(s)
indirect immunofluorescence: 1:100-1:200
isotype
IgG
immunogen sequence
(I-G-S-L-D)
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... MAPT(4137)
General description
MAPT (microtubule associated protein tau) is located on human chromosome 17q21.3. It is upregulated in neurons but is most prominent in axons.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
Immunogen
Peptide sequence around aa. 354-358 (I-G-S-L-D), according to the protein MAPT.
Biochem/physiol Actions
Removal of MAPT results in developmental delay and learning disability. It participates in the pathology of Alzheimer′s disease (AD). It helps in the assembly and maintenance of microtubule structure.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Solution in phosphate-buffered saline containing 0.02% sodium azide and 50% glycerol
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Microdeletion encompassing MAPT at chromosome 17q21.3 is associated with developmental delay and learning disability
Shaw-Smith C
Nature Genetics, 38(9), 1032-1037 (2006)
Linkage disequilibrium and association of MAPT H1 in Parkinson disease
Skipper L, et al.
American Journal of Human Genetics, 75(4), 669-677 (2004)
The H1c haplotype at the MAPT locus is associated with Alzheimer's disease
Myers AJ, et al.
Human Molecular Genetics, 14(16), 2399-2404 (2005)
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