SAB4500545
Anti-Catenin-β antibody produced in rabbit
affinity isolated antibody
别名:
CATNB, CTNB1, CTNNB, catenin β, catenin (cadherin-associated protein) β 1
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关于此项目
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA, WB
Citations:
4
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 85 kDa
species reactivity
rat, mouse, human
concentration
~1 mg/mL
technique(s)
ELISA: 1:40000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... CTNNB1(1499)
General description
Anti-Catenin-β Antibody detects endogenous levels of total Catenin-β protein.
Catenin-β is a multifunctional protein, coded by CTNNB1 (catenin β 1) gene. It is present in the intracellular side of the cytoplasmic membrane. It is located on human chromosome 3p22.1.
Immunogen
The antiserum was produced against synthesized peptide derived from human Catenin-beta.
Immunogen Range: 455-504
Immunogen Range: 455-504
Biochem/physiol Actions
Mutations in β-Catenin results in retinal vascular condition FEVR (familial exudative vitreoretinopathy). It participates in stimulating disease progression, providing to BCR–ABL (fusion gene) kinase-independent resistance and LSC (leukemic stem cell) self-renewal. It plays an important role in cell-to-cell adhesion and transcriptional modulation in the Wnt signalling pathway.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
低风险生物材料
此项目有
Combined inhibition of ?-catenin and Bcr-Abl synergistically targets tyrosine kinase inhibitor-resistant blast crisis chronic myeloid leukemia blasts and progenitors in vitro and in vivo
Zhou H, et al.
Leukemia, 31(10), 2065-2074 (2017)
?-Catenin pathway activation in breast cancer is associated with triple-negative phenotype but not with CTNNB1 mutation
Geyer FC, et al.
Modern Pathology, 24(2), 209-231 (2011)
Defects in the Cell Signaling Mediator ?-Catenin Cause the Retinal Vascular Condition FEVR
Panagiotou ES, et al.
American Journal of Human Genetics, 100(6), 960-968 (2017)
Jessica Neville Little et al.
Human molecular genetics, 28(3), 434-447 (2018-10-12)
Building a cerebral cortex of the proper size involves balancing rates and timing of neural stem cell (NSC) proliferation, neurogenesis and cell death. The cellular mechanisms connecting genetic mutations to brain malformation phenotypes are still poorly understood. Microcephaly may result
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