biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
mol wt
antigen 55 kDa
species reactivity
mouse, human, rat
concentration
~1 mg/mL
technique(s)
ELISA: 1:10000, western blot: 1:500-1:1000
NCBI accession no.
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
phosphorylation (pTyr380)
Quality Level
Gene Information
human ... CASP8(841)
General description
Caspase-8 (CASP8) is a member of the cysteine aspartate-specific proteases family. It is produced in the cell as procaspase-8, a sluggish zymogen. Procaspase-8 has a long prodomain, carrying two major protein interaction domains, DED1 and DED2, followed by one large (p18) and one small (p10) catalytic subunit. CASP8 is mapped to human chromosome 2q33.
Immunogen
The antiserum was produced against synthesized peptide derived from human Caspase 8 around the phosphorylation site of Tyr380.
Immunogen Range: 346-395
Immunogen Range: 346-395
Biochem/physiol Actions
Caspase-8 (CASP8) is involved in apoptosis, inflammation and cellular differentiation. It activates programmed cell death, after death receptor ligation. Casp8 is essential for the clonal expansion of T and B cell. It also participates in lymphocyte homeostasis.
Features and Benefits
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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存储类别
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
低风险生物材料
常规特殊物品
此项目有
Functions of Caspase 8: the Identified and the Mysterious.
Guy SS and Craig MW
Seminars in Immunology, 26(3), 246?252-246?252 (2014)
Structure and chromosome localization of the human CASP8 gene.
Jose GA, et al.
Gene, 226(2), 225-232 (1999)
Caspase-8, association with Alzheimer?s Disease and functional analysis of rare variants.
Jan R, et al.
PLoS ONE, 12(10), e0185777-e0185777 (2017)
Dwayne G Stupack
Cancer letters, 332(2), 133-140 (2010-09-08)
Caspase-8 is an apical caspase which initiates programmed cell death following death receptor ligation. This central role in apoptosis has prompted significant clinical interest in regulating caspase-8 expression and proteolytic activity. However, caspase-8 has also been found to play a
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