Monoclonal Anti-STRO-1 antibody produced in mouse

The mouse monoclonal antibody STRO-1 recognizes the cell surface antigen STRO-1 expressed by bone marrow mesenchymal stromal cells and nucleated erythroid precursors, but not by committed hematopoietic progenitors.

Human CD34 positive bone marrow cells

STRO-1 plays a vital role as a mesenchymal stem cell (MSC) marker. This 75kDa endothelial protein has a capacity to differentiate into multiple mesenchymal lineages such as hematopoiesis supportive stromal cells with a vascular smooth muscle like phenotype, as well as adipocytes, osteoblasts and chondrocytes. STRO-1 antibody has been used to separate stromal precursors from freshly aspirated bone marrow (BM) cell suspensions.

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Solution in Tris buffered saline, pH 8.0, with 15 mM sodium azide.

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