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SBR00121

Amphotericin B water soluble

Name: Amphotericin B water soluble
Brand: SIGMA

from semisynthetic, powder

别名:

AmB, Amphotericin

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About This Item

经验公式（希尔记法）:

C₅₁H₈₂N₂O₁₉

分子量:

1027.20

UNSPSC代码:

51302401

生物来源

fermentation/recombinant
semisynthetic

质量水平

200

方案

≥90% (HPLC)

表单

powder

储存条件

protect from light

颜色

light yellow to very dark yellow, to very dark brown

作用机制

cell membrane | interferes

运输

dry ice

储存温度

−20°C

适用性

fungi
yeasts

SMILES字符串

C[C@@H](O1)[C@@H](O)[C@H]([NH3+])[C@H](O)[C@]1([H])O[C@H](C[C@@]2([H])[C@@H]([C@@H](O)C[C@@](O2)(O)C[C@@H](O)C[C@@H](O)[C@H](O)CC[C@@H](O)C[C@@H](O)C3)C(NCCO)=O)/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC3=O.CC([O-])=O

InChI

1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1

InChI key

APKFDSVGJQXUKY-INPOYWNPSA-N

一般描述

Amphotericin B is a polyene antifungal antibiotic which has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Amphotericin B water soluble is a synthetic derivative of AmB that preserves the antifungal activity but is highly miscible in water up to 100 mg/mL.

生化/生理作用

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. Antimicrobial spectrum: Includes fungi and yeast It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast.

特点和优势

Easily soluble in water up to 100mg/mL
Animal component free
Tested for cell toxicity
Can be 0.2µm filtered

制备说明

Amphotericin B water soluble can be directly dissolved in the media to a working concentration of 2.5 mg/L.

其他说明

Product is sensitive to light.

象形图

GHS08

警示用语：

Danger

危险声明

H372

预防措施声明

P260 - P264 - P270 - P314 - P501

危险分类

STOT RE 1

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

0000403478

0000337898