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Merck
CN

SMB00424

桔梗皂苷D

≥98% (HPLC)

别名:

3β-(β-D-吡喃葡萄糖基氧基)-2β,16α,23,24-四羟基-O-D-apio-β-D-呋喃基-(1→3)-O-β-D-吡喃木糖基-(1→4)-O-6-脱氧-齐墩果-12-烯-28-酸

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关于此项目

经验公式（希尔记法）:
C57H92O28
化学文摘社编号:
58479-68-8
分子量:
1225.32
UNSPSC Code:
12352205
PubChem Substance ID:
329825010
NACRES:
NA.25

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SMILES string

O[C@@H]1[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O2)C(CO)(CO)[C@]3([H])CC[C@@]4(C)[C@]5(C)C[C@@H](O)[C@@]6(C(O[C@H]7[C@H](O[C@@H]8O[C@@H](C)[C@H](O[C@H]9[C@H](O)[C@@H](O[C@@H]%10OC[C@@](CO)(O)[C@H]%10O)[C@H](O)CO9)[C@@H](O)[C@H]8O)[C@@H](O)[C@@H](O

InChI

1S/C57H92O28/c1-23-40(81-45-39(72)41(30(64)18-76-45)82-49-43(73)56(75,21-61)22-78-49)36(69)38(71)46(79-23)83-42-33(66)29(63)17-77-48(42)85-50(74)57-12-11-51(2,3)14-27(57)24-7-9-52(4)26-13-28(62)44(84-47-37(70)35(68)34(67)31(16-58)80-47)55(19-59,20-60)25(26)8-10-54(52,6)53(24,5)15-32(57)65/h7,23,25-49,58-73,75H,8-22H2,1-6H3/t23-,25+,26-,27-,28-,29-,30+,31+,32+,33-,34+,35-,36-,37+,38+,39+,40-,41-,42+,43-,44-,45-,46-,47-,48?,49-,52+,53+,54+,56+,57+/m0/s1

InChI key

RJDYKSRQTBCKLC-XTIQGCOGSA-N

assay

≥98% (HPLC)

form

powder

application(s)

metabolomics
vitamins, nutraceuticals, and natural products

storage temp.

2-8°C

Quality Level

200

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相关类别

General description

桔梗皂苷D (platycodin D)是从桔梗根(Platycodonis Radix)中提取的一种三萜皂苷。

Application

桔梗皂苷D已用于：
  • 使用卵清白蛋白(OVA)诱导的过敏性哮喘小鼠模型，检测其对嗜酸性气道炎症和2型助性T细胞(Th2)信号通路的抗炎和抑制作用
  • 在体内和体外研究中，检测其激活褐色脂肪组织的抗肥胖作用
  • 检测其作为鸡传染性支气管炎(IB)疫苗佐剂的效能

Biochem/physiol Actions

桔梗皂苷D具有较强的抗癌性，对体外和体内来源的多种肿瘤细胞株均具有细胞毒性作用。可通过上调肝X受体α(LXRα)和ATP-结合盒转运蛋白A1(ABCA1)信号传导通路，发挥对脂多糖(LPS)诱导的急性肺损伤(ALI)具有抗炎和保护功效。也对顺铂诱导(CDDP)的小鼠肾毒性具有保护作用。

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

法规信息

动植物源性产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
SLCQ2720
SLCM5355
SLCQ0645
SLCP3465
SLCJ3571

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Eung Gu Lee et al.
The Journal of asthma : official journal of the Association for the Care of Asthma, 1-11 (2021-06-16)
Introduction: Bronchial asthma is a common chronic inflammatory condition of the airway tissue. Platycodin D (PLD) has antiinflammatory effects in a mouse model of allergic asthma. In this work, the anti-asthma potential of PLD was studied by investigation of its
J L Gajewski et al.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology, 7(11), 1637-1645 (1989-11-01)
One hundred ninety-six patients with acute myelogenous leukemia (AML) were treated with intensive induction chemotherapy using similar daunorubicin/cytarabine/thioguanine regimens. Treatment results of 44 patients who had a documented preleukemic syndrome or cytopenia present for more than 2 months before developing
Tae-Won Kim et al.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 50(12), 4254-4259 (2012-05-24)
Platycodin D (PD) is well known as a potent triterpenoid saponin having various pharmacological activities isolated from the root of Platycodon grandiflorum (Jacq.) A. DC. (Campanulaceae). We aimed to evaluate protective effect of PD on cisplatin (CDDP)-induced nephrotoxicity. Male ICR
Yefei Zhou et al.
The journal of poultry science, 57(2), 160-167 (2020-05-29)
Adjuvants are common vaccine components. Novel adjuvants may improve the protective immunity conferred by vaccines against poultry diseases. Here, a less-hemolytic saponin, platycodin D (PD), isolated from the root of Platycodon grandiflorum was investigated as a potential alternative adjuvant. PD
Muhammad Khan et al.
Journal of cellular and molecular medicine, 20(3), 389-402 (2015-12-10)
Cancer is a multi-faceted disease comprised of a combination of genetic, epigenetic, metabolic and signalling aberrations which severely disrupt the normal homoeostasis of cell growth and death. Rational developments of highly selective drugs which specifically block only one of the
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