SMB01050
Licochalcone B
≥85% (LC/MS-ELSD)
别名:
(E)-3-(3,4-dihydroxy-2-methoxyphenyl)-1-(4-hydroxyphenyl)prop-2-en-1-one, 3,4,4′-trihydroxy-2-methoxychalcone
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关于此项目
经验公式（希尔记法）:
C16H14O5
化学文摘社编号:
分子量:
286.28
UNSPSC Code:
12352205
NACRES:
NA.25
MDL number:
SMILES string
O(C)c1c(c(ccc1\C=C\C(=O)c2ccc(cc2)O)O)O
InChI
1S/C16H14O5/c1-21-16-11(5-9-14(19)15(16)20)4-8-13(18)10-2-6-12(17)7-3-10/h2-9,17,19-20H,1H3/b8-4+
InChI key
DRDRYGIIYOPBBZ-XBXARRHUSA-N
biological source
plant
assay
≥85% (LC/MS-ELSD)
form
solid
mol wt
286.28
solubility
water: slightly soluble
application(s)
metabolomics
vitamins, nutraceuticals, and natural products
storage temp.
−20°C
General description
Licochalcone B is a prenylated flavonoid classified within the group of retrochalcones. This bioactive natural compound is commonly sourced from Glycyrrhiza species (G. glabra, G. uralensis, G. inflata, and G. aspera) plants. Existing research indicates that this plant-derived metabolite possesses a wide array of biological activities, including antibacterial, cardioprotective, anticancer, antioxidant, antiapoptotic, neuroprotective and anti-inflammatory properties.
Application
It is a natural product derived from plant source that finds application in compound screening libraries, metabolomics, phytochemical, and pharmaceutical research.
Biochem/physiol Actions
According to the existing research, Licochalcone B exerts its effects through multiple pathways, making it a versatile candidate for various therapeutic applications. It effectively combats inflammation by inhibiting NF-κB activation induced by LPS, leading to reduced production of NO, TNFα, and MCP-1. For bladder cancer, Licochalcone B demonstrates its potential by inducing S phase arrest, modulating cell cycle-related proteins, suppressing anti-apoptotic factors, and activating caspase-3. These actions collectively limit tumor growth in vivo, suggesting its utility in both bladder cancer therapy and prevention. Furthermore, Licochalcone B showcases robust antioxidant capabilities, successfully mitigating lipid peroxidation and lowering ROS production. It also exhibits anti-inflammatory properties by decreasing the release of NO, IL-6, and PGE2 in response to LPS. Furthermore, Licochalcone B emerges as a promising candidate for Alzheimer′s disease treatment, effectively preventing Aβ42 aggregation, chelating metal ions, and providing neuroprotection.
Features and Benefits
- High quality compound suitable for multiple research applications
- Compatible with HPLC and mass spectrometry techniques
Other Notes
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存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Ze-Feng Wang et al.
Current medicinal chemistry, 27(12), 1997-2011 (2018-10-03)
Plants have always been an important source of medicines for humans, and licorice is a very significant herb in the development of humans. As a traditional herb, it is widely cultivated in China, Japan, Russia, Spain and India. With the
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