SML0116
GW788388 Hydrate
≥98% (HPLC), TGFβ signalling inhibitor, powder
别名:
4-{4-[3-(Pyridin-2-yl)-1H-pyrazol-4-yl]-pyridin-2-yl}-N-(tetrahydro-2H-pyran-4-yl)benzamide hydrate
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选择尺寸
关于此项目
经验公式（希尔记法）:
C25H23N5O2 · xH2O
分子量:
425.48 (anhydrous basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
MDL number:
产品名称
GW788388 Hydrate, ≥98% (HPLC)
SMILES string
O.O=C(NC1CCOCC1)c2ccc(cc2)-c3cc(ccn3)-c4c[nH]nc4-c5ccccn5
InChI
1S/C25H23N5O2.H2O/c31-25(29-20-9-13-32-14-10-20)18-6-4-17(5-7-18)23-15-19(8-12-27-23)21-16-28-30-24(21)22-3-1-2-11-26-22;/h1-8,11-12,15-16,20H,9-10,13-14H2,(H,28,30)(H,29,31);1H2
InChI key
VZRJMBZMFKADGR-UHFFFAOYSA-N
assay
≥98% (HPLC)
form
powder
color
white to tan
solubility
DMSO: ≥8 mg/mL
originator
GlaxoSmithKline
storage temp.
2-8°C
Quality Level
Biochem/physiol Actions
GW788388 is a potent selective inhibitor of TGF-beta type I receptor [activin receptor-like kinase 5 (ALK5)]. GW788388 is orally available with a half-life of approximately 4 hours.
TGFβ1 (ALK5) inhibitor; Potent, selective inhibitor of TGFβ signalling in vitro and renal fibrosis in vivo
Features and Benefits
This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral - Aquatic Acute 1
存储类别
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
Min Cheol Pyo et al.
Archives of toxicology, 94(9), 3329-3342 (2020-07-04)
Ochratoxin A (OTA) is a toxin produced by fungi such as Aspergillus spp. and Penicillium spp. The key target organ of OTA toxicity is the kidney, and it is known that epithelial-to-mesenchymal transition (EMT) leading to fibrosis is enhanced after
Yunmee Lho et al.
International journal of molecular sciences, 22(9) (2021-05-06)
We investigated the effectiveness of the transforming growth factor beta-1 (TGF-β) receptor inhibitor GW788388 on the epithelial to mesenchymal transition (EMT) using human peritoneal mesothelial cells (HPMCs) and examined the effectiveness of GW788388 on the peritoneal membrane using a peritoneal
Hsiu-Hui Yang et al.
Frontiers in physiology, 13, 816959-816959 (2022-06-11)
Water permeability of the kidney collecting ducts is regulated in part by the amount of the molecular water channel protein aquaporin-2 (AQP2), whose expression, in turn, is regulated by the pituitary peptide hormone vasopressin. We previously showed that stable glucocorticoid
Paul Jennings et al.
Cell biology and toxicology (2023-01-01)
Transcriptomic analysis is a powerful method in the utilization of New Approach Methods (NAMs) for identifying mechanisms of toxicity and application to hazard characterization. With this regard, mapping toxicological events to time of exposure would be helpful to characterize early
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