SML1232
cGAMP 钠盐
≥98% (HPLC), IFN-β production inducer, powder
别名:
3′3′-cGAMP 钠盐, c-GMP-AMP 钠盐, 环 AMP—GMP 钠盐, 环 GMP-AMP 钠盐
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关于此项目
经验公式（希尔记法）:
C20H24N10O13P2 · xNa+
化学文摘社编号:
分子量:
674.41 (free acid basis)
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
产品名称
cGAMP 钠盐, ≥98% (HPLC)
description
contains 0.5μmol of powder (approx. 0.335mg)
Quality Level
assay
≥98% (HPLC)
form
powder
color
white to beige
storage temp.
−20°C
SMILES string
O=C1N=C(N)NC2=C1N=CN2[C@H](O3)[C@H](O)[C@H](OP4(O)=O)[C@H]3COP(O)(O[C@H]5[C@@H](O)[C@H](N6C=NC7=C6N=CN=C7N)O[C@@H]5CO4)=O.C
Application
cGAMP 钠盐已用于 cGAS-cGAMP 活性测定。
Biochem/physiol Actions
cGAMP 诱导细胞因子（干扰素-β，干扰素-γ）激活树突状细胞和 CD8 + T 细胞交叉致敏。通过这一操作，促进天然免疫反应。cGAMP 具有抗肿瘤活性，在癌症治疗中首选用于免疫治疗。
环腺苷酸 GMP (cGAMP) 是细菌第二信使。
环腺苷酸-GMP (cGAMP) 是几种天然存在的环二核苷酸之一，作为细菌第二信使调控原核生物中控制细菌存活、黏附、定植、生物膜形成和毒力因子产生的重要信号机制。霍乱时 c-AMP-GMP 通过下调趋化性促进肠道定植。在感染过程中，细菌 cGAMP 与宿主 STING（干扰素基因刺激物）结合，激活先天免疫应答，导致干扰素基因的表达。
Preparation Note
环 AMP-GMP 可溶于水和水性缓冲液（> 10 mM，尚未确定限度）。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
商品
Bioactive small molecules for immune system signaling target identification/validation and antibiotics, antivirals, and antifungals offered.
Yong Shen et al.
Cell reports, 35(12), 109272-109272 (2021-06-24)
The type I interferon (IFN) pathway is a key component of innate immune response upon invasion of foreign pathogens. It is also under precise control to prevent excessive upregulation and undesired inflammation cascade. In the present study, we report that
Antitumor activity of cGAMP via stimulation of cGAS-cGAMP-STING-IRF3 mediated innate immune response.
Li T, et al.
Scientific Reports, 6, 19049-19049 (2016)
Andrea Annibal et al.
Analytical and bioanalytical chemistry, 413(26), 6457-6468 (2021-09-04)
Cyclic dinucleotides (CDNs) are key secondary messenger molecules produced by cyclic dinucleotide synthases that trigger various cellular signaling cascades from bacteria to vertebrates. In mammals, cyclic GMP-AMP synthase (cGAS) has been shown to bind to intracellular DNA and catalyze the
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| SML1232-.5UMO | 04061832636672 |