SRP6156
BMP-4 human
recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)
别名:
BMP-2B, Bone morphogenetic protein 2B, Bone morphogenetic protein 4
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关于此项目
NACRES:
NA.32
UNSPSC Code:
12352202
Form:
lyophilized
Assay:
≥95% (SDS-PAGE)
Biological source:
human
Recombinant:
expressed in HEK 293 cells
Mol wt:
34 kDa (homodimer, glycosylated.)
biological source
human
recombinant
expressed in HEK 293 cells
assay
≥95% (SDS-PAGE)
form
lyophilized
potency
2-10 ng/mL
mol wt
34 kDa (homodimer, glycosylated.)
packaging
pkg of 10 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
<1 EU/μg protein Endotoxin level (LAL test)
NCBI accession no.
shipped in
dry ice
storage temp.
−20°C
Gene Information
human ... BMP4(652)
General description
BMP4 (bone morphogenetic protein 4), a member of the highly conserved BMP family, is a growth factor and a pro-inflammatory and pro-atherogenic cytokine. BMPs are part of the TGFβ (tumor growth factor) superfamily of proteins. BMP4 gene is localized to human chromosome 14q22-q23.
Biochem/physiol Actions
BMP4 (bone morphogenetic protein 4) is involved in modulating cell development in a wide variety of cells. It promotes the proliferation and migration of hepatocellular carcinoma cells, and the multiplication of ALK3 (activin-like kinase)-positive cells in skeletal muscle. This protein prevents the proliferation of lung fibroblasts and induces their differentiation into myocytes. In Sertoli cells, it promotes DNA synthesis and hence, the proliferation of Sertoli cells through Smad1/5 (small mothers against decapentaplegic) and ID2/3 (DNA binding protein inhibitor) pathway, and aberration in BMP4 expression results in azoospermia. In human males, the serum levels of BMP4 is linked with coronary artery disease (CAD) severity. BMP4 is crucial for maintaining the self-renewal capacity of ES (embryonic stem) cells, and achieves so by inhibiting extracellular receptor kinase (ERK) and p38 mitogen-activated protein kinase (MAPK) pathways.
Physical form
Lyophilized from a PBS solution.
Preparation Note
Centrifuge the vial prior to opening.
Reconstitute in sterile 4 mM HCl containing 0.1% endotoxin-free recombinant human serum albumin.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
监管及禁止进口产品
此项目有
Bmp4 is required for the generation of primordial germ cells in the mouse embryo.
Lawson KA et al
Genes & Development, 13(4), 424-436 (1999)
BMP4 promotes human Sertoli cell proliferation via Smad1/5 and ID2/3 pathway and its abnormality is associated with azoospermia.
Hai Y et al
Discovery Medicine, 19(105), 311-325 (2015)
Serum Bone Morphogenic Protein-4 Contributes to Discriminating Coronary Artery Disease Severity.
Park CS et al
Medicine, 94(3), e1530-e1530 (2015)
BMP4 supports self-renewal of embryonic stem cells by inhibiting mitogen-activated protein kinase pathways.
Qi X et al
Proceedings of the National Academy of Sciences of the USA, 101(16), 6027-6032 (2004)
Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis.
Weaver M et al
Development, 127(12), 2695-2704 (2000)
商品
Role of growth factors in stem cell differentiation and various growth factors for your research at sigmaaldrich.com
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