T1895
胸苷
powder, BioReagent, suitable for cell culture
别名:
1-(2-脱氧-β-D-呋喃核糖)-5-甲基尿嘧啶, 1-(2-脱氧-β-D-呋喃核糖)胸苷, 2′-脱氧胸苷, dT, 胸腺嘧啶核苷
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关于此项目
经验公式（希尔记法）:
C10H14N2O5
化学文摘社编号:
分子量:
242.23
UNSPSC Code:
12352207
NACRES:
NA.75
PubChem Substance ID:
EC Number:
200-070-4
Beilstein/REAXYS Number:
89285
MDL number:
Assay:
≥99%
Biological source:
synthetic (organic)
Form:
powder
Solubility:
water: 50 mg/mL, clear, colorless
biological source
synthetic (organic)
Quality Level
product line
BioReagent
assay
≥99%
form
powder
technique(s)
cell culture | mammalian: suitable
mp
186-188 °C (lit.)
solubility
water: 50 mg/mL, clear, colorless
SMILES string
CC1=CN([C@H]2C[C@H](O)[C@@H](CO)O2)C(=O)NC1=O
InChI
1S/C10H14N2O5/c1-5-3-12(10(16)11-9(5)15)8-2-6(14)7(4-13)17-8/h3,6-8,13-14H,2,4H2,1H3,(H,11,15,16)/t6-,7+,8+/m0/s1
InChI key
IQFYYKKMVGJFEH-XLPZGREQSA-N
Gene Information
human ... DTYMK(1841)
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General description
胸苷又称为嘧啶脱氧核苷。脱氧胸苷是DNA中存在的核苷。在DNA双链结构中，胸苷与脱氧腺苷配对。
Application
胸苷可用在HT和HAT混合物中，用于杂交瘤融合、筛选和克隆。它已用于：
- 用作基础培养基中的核苷酸来源，以评估iSCNT分化胚泡的生长
- 作为杜氏改良Eagle培养基（DMEM）选择培养基的补充成分，用于制备抗神经素（NRGN）抗体
- 用于制备THMG（胸腺嘧啶、次黄嘌呤、甘氨酸、甲氨蝶呤）和THG储备液，清洁小鼠淋巴瘤细胞
Biochem/physiol Actions
胸苷可用于S期细胞同步。在嘧啶的补救合成途径中，嘧啶磷酸化酶将胸腺嘧啶可逆转化为胸苷。
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Human Biochemistry and Disease, 571-571 (2008)
Molecular Biology, Principles of Genome Function: Biology, Molecular biology (2016)
Serum neurogranin measurement as a biomarker of acute traumatic brain injury
Yang J, et al.
Clinical Biochemistry, 43(13-14), 843-848 (2015)
Optimization in Drug Discovery: In Vitro Methods (2016)
Dominique Desbouis et al.
Journal of medicinal chemistry, 51(21), 6689-6698 (2008-10-08)
Human cytosolic thymidine kinase (hTK1) has proven to be a suitable target for noninvasive imaging of cancer cell proliferation using radiolabeled substrates such as [ (18)F]fluorothymidine ([ (18)F]FLT). However, a thymidine tracer useful for single photon emission tomography (SPECT) based
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T1895-5G | 04061837338366 |
| T1895-10G | 04061837338342 |
| T1895-1G | 04061835569564 |
| T1895-25G | 04061837338359 |
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