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T2379

筒箭毒碱 盐酸盐 五水合物

≥97%, neuromuscular blocker

别名:

(+)-Tubocurarine hydrochloride

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关于此项目

经验公式（希尔记法）:
C37H41ClN2O6 · HCl · 5H2O
化学文摘社编号:
6989-98-6
分子量:
771.72
UNSPSC Code:
12352200
PubChem Substance ID:
24900034
NACRES:
NA.77
MDL number:
MFCD00150157
Assay:
≥97%
Quality level:
200
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产品名称

筒箭毒碱 盐酸盐 五水合物, ≥97%

Quality Level

200

assay

≥97%

solubility

H2O: soluble 50 mg/ml, with heating as required, clear to slightly hazy, colorless to yellow, ethanol: soluble, methanol: soluble

storage temp.

2-8°C

SMILES string

O.O.O.O.O.Cl.[Cl-].COc1cc2CCN(C)[C@H]3Cc4ccc(Oc5c(O)c(OC)cc6CC[N+](C)(C)[C@H](Cc7ccc(O)c(Oc1cc23)c7)c56)cc4

InChI

1S/C37H40N2O6.2ClH.5H2O/c1-38-14-12-24-19-32(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-37-35-25(20-34(43-5)36(37)41)13-15-39(2,3)29(35)17-23-8-11-30(40)31(18-23)45-33;;;;;;;/h6-11,18-21,28-29H,12-17H2,1-5H3,(H-,40,41);2*1H;5*1H2/t28-,29+;;;;;;;/m0......./s1

InChI key

WMIZITXEJNQAQK-GGDSLZADSA-N

Gene Information

human ... CHRNA1(1134), CHRNB1(1140), CHRND(1144), CHRNE(1145), CHRNG(1146)

相关类别

Application

Tubocurarine hydrochloride pentahydrate has been used as a acetylcholinesterase inhibitor (Ach) inhibitor in myotubes, muscle and as neuromuscular junction blocker in zebra fish embryos.

Biochem/physiol Actions

Tubocurarine is a muscle relaxant and a nicotinic acetylcholine receptor antagonist. It can induce neuromuscular blocking.

Features and Benefits

This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Preparation Note

Tubocurarine hydrochloride pentahydrate is soluble in water at 50 mg/ml (with heat as required) and yields a clear to slightly hazy, colorless to yellow solution. It is also soluble in methanol and ethanol.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

存储类别

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

法规信息

剧毒化学品
涉药品监管产品

此项目有

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCCN0590
BCCH9523
BCCC1458
BCBV5179
BCBR4715V

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The kinetics of inhibition of nicotinic acetylcholine receptors by (+)-tubocurarine and pancuronium
Wenningmann I and Dilger JP
Molecular Pharmacology, 60(4), 790-796 (2001)
Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis
Gomez A, et al.
Journal of immunology (Baltimore, Md. : 1950), 186(4), 2503-2513 (2011)
Resistance to d-Tubocurarine of the Rat Diaphragm as Compared to a Limb MuscleInfluence of Quantal Transmitter Release and Nicotinic Acetylcholine Receptors
Nguyen-Huu, T, et al.
Anesthesiology, 110(5), 1011-1015 (2009)
Gerta Vrbova et al.
The European journal of neuroscience, 30(3), 366-375 (2009-08-07)
There are receptors on denervated Schwann cells that may respond to the neurotransmitters that are released from growth cones of regenerating motor axons. In order to ascertain whether the interaction of the transmitters and their receptors plays a role during
Proteasome inhibition with bortezomib depletes plasma cells and autoantibodies in experimental autoimmune myasthenia gravis
Muto A, et al.
Proceedings of the National Academy of Sciences of the USA, 108(13), 5425-5425 (2011)
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全球贸易项目编号

货号GTIN
T2379-100MG04061835260980

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