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T3165

7-Methoxy-4-(trifluoromethyl)coumarin

≥99% (TLC)

别名:

Methyl 4-(trifluoromethyl)umbelliferyl ether

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关于此项目

经验公式（希尔记法）:
C11H7F3O3
化学文摘社编号:
575-04-2
分子量:
244.17
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
24900113
MDL number:
MFCD00132980
Beilstein/REAXYS Number:
225039
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Quality Level

200

assay

≥99% (TLC)

form

powder

solubility

acetone: 50 mg/mL, clear, colorless to faintly yellow

fluorescence

λex 333 nm; λem 416 nm in methanol

SMILES string

COc1ccc2c(OC(=O)C=C2C(F)(F)F)c1

InChI

1S/C11H7F3O3/c1-16-6-2-3-7-8(11(12,13)14)5-10(15)17-9(7)4-6/h2-5H,1H3

InChI key

HAZHUELNIGDYQH-UHFFFAOYSA-N

Application

7-Methoxy-4-(trifluoromethyl)coumarin has been used as a substrate in cytochrome P450 2E1 (CYP2E1) activity assay and aromatase assay.

Biochem/physiol Actions

The enzymatic action of cytochrome P450 2E1 (CYP2E1) on 7-methoxy-4-(trifluoromethyl)coumarin results in a fluorescent product 7-hydroxy-4-(trifluoromethyl)coumarin (HFC) that can be measured at 409/530 nm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000532596
0000532596
BGBB7386V
BGBB7386
097K2586

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Rebeca Santes-Palacios et al.
Toxicology in vitro : an international journal published in association with BIBRA, 69, 105009-105009 (2020-10-03)
Cytochrome P450 2E1 (CYP2E1) has been proposed as a molecular target in oxidative stress-associated metabolic diseases. Rats are chosen as model organisms in most experiments studying CYP2E1-related toxicity; however, the human relevance of these results remains unclear. To describe differences
Carlo Matera et al.
European journal of pharmacology, 820, 265-273 (2017-12-25)
(±)-3-Methoxy-1-oxa-2,7-diaza-7,10-ethanospiro[4.5]dec-2-ene sesquifumarate (±)-1 was previously characterized as the most selective agonist at α7 neuronal nicotinic acetylcholine receptors in a series of spirocyclic quinuclidinyl-Δ
Gaku Okamatsu et al.
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全球贸易项目编号

货号GTIN
T3165-100MG04061837343841