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Merck
CN

T3757

TTNPB

retinoic acid analog

别名:

4- [(E)-2-（5,6,7,8-四氢-5,5,8,8-四甲基-2-萘基）-1-丙烯基] 苯甲酸, 芳香烃酸

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关于此项目

经验公式（希尔记法）:
C24H28O2
化学文摘社编号:
71441-28-6
分子量:
348.48
UNSPSC Code:
12352200
PubChem Substance ID:
24278733
NACRES:
NA.77
MDL number:
MFCD00673917
Quality level:
200

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产品名称

TTNPB,

Quality Level

200

solubility

ethanol: soluble 10 mM, DMSO: soluble 25 mM, chloroform/methanol: soluble 9.80-10.20 mg/mL, clear, colorless to light yellow

storage temp.

−20°C

SMILES string

C\C(=C/c1ccc(cc1)C(O)=O)c2ccc3c(c2)C(C)(C)CCC3(C)C

InChI

1S/C24H28O2/c1-16(14-17-6-8-18(9-7-17)22(25)26)19-10-11-20-21(15-19)24(4,5)13-12-23(20,2)3/h6-11,14-15H,12-13H2,1-5H3,(H,25,26)/b16-14+

InChI key

FOIVPCKZDPCJJY-JQIJEIRASA-N

Gene Information

human ... RARA(5914), RARB(5915), RARG(5916), RXRA(6256), RXRB(6257), RXRG(6258)

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相关类别

Application

已将 TTNPB 用于 293T 细胞的转录分析 4 。它也被用作培养的人脐血 CD34 + CD38 - lin - 细胞 5 的 RAR 激动剂。

Biochem/physiol Actions

对视黄酸受体 (RAR) α 具有亲和力的选择性和高效的视黄酸类似物, β和 γ为核转录因子。产生具有视黄酸应答元件的基因的配体激活转录。

Features and Benefits

该化合物在受体分类和信号转导手册中 核受体（非甾体化合物） 页面中进行了详细介绍。欲浏览其他手册页面，请 点击这里。

Preparation Note

TTNPB 溶于 9.80-10.20 mg/mL 的 CHCL3/MeOH (1/1) 中，得到澄清、无色至淡黄色溶液。溶于乙醇 (10 mM) 和 DMSO (25 mM)。

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Danger

Hazard Classifications

Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000469859
0000469859
0000403022
0000403022
0000347117

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Bryan R Haugen et al.
The Journal of clinical endocrinology and metabolism, 89(1), 272-280 (2004-01-13)
Therapy for patients with advanced thyroid carcinoma is limited. Clinical and in vitro studies suggest that some patients with advanced thyroid cancer may respond to therapy with retinoic acid. mRNA expression of the six retinoic acid (RAR) and retinoid X
Olivier M Niemoeller et al.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology, 21(1-3), 193-202 (2008-01-23)
Vitamin A and retinoic acid have previously been shown to confer some protection against a severe course of malaria by fostering the phagocytosis of parasitized erythrocytes. Phagocytosis of erythrocytes is stimulated by phosphatidylserine exposure at the cell surface. The present
Matthias W Büttner et al.
Chembiochem : a European journal of chemical biology, 8(14), 1688-1699 (2007-09-05)
Twofold sila-substitution (C/Si exchange) in the saturated ring of the tetrahydronaphthalene skeleton of the retinoid agonists TTNPB (1 a) and 3-methyl-TTNPB (2 a) leads to disila-TTNPB (1 b) and disila-3-methyl-TTNPB (2 b), respectively. The silicon compounds 1 b and 2
John S Bertram et al.
Biochimica et biophysica acta, 1740(2), 170-178 (2005-06-14)
Virtually all human tumors are deficient in gap junctional communication (GJC) and the restoration of GJC by forced expression of connexins reduces indices of neoplasia. The expression of connexin 43 (Cx43) is upregulated by cancer-preventive retinoids and carotenoids which correlates
Karine Hellemans et al.
Hepatology (Baltimore, Md.), 39(1), 97-108 (2004-01-31)
Activation of hepatic stellate cells (HSC) is a central event in the pathogenesis of liver fibrosis during chronic liver injury. We examined the expression of retinoic acid (RAR) and retinoid X receptors (RXR) during HSC activation and evaluated the influence
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全球贸易项目编号

货号GTIN
T3757-10MG04061837344992

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