T6140
N-(对甲苯磺酰基)-甘氨酸-脯氨酸-赖氨酸-4-硝基苯胺 乙酸盐
plasmin substrate, chromogenic, ≥98% (TLC), powder
别名:
N-甲苯磺酰基甘氨酰-L-脯氨酰-L-赖氨酸-4-硝基苯胺 乙酸盐
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关于此项目
线性分子式:
C26H34N6O7S · C2H4O2
化学文摘社编号:
分子量:
634.70
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352204
EC Number:
289-446-7
MDL number:
产品名称
N-(对甲苯磺酰基)-甘氨酸-脯氨酸-赖氨酸-4-硝基苯胺 乙酸盐, plasmin substrate
Quality Level
assay
≥98% (TLC)
form
powder
solubility
ethanol: 50 mg/mL, colorless to yellow
storage temp.
−20°C
SMILES string
CC(O)=O.Cc1ccc(cc1)S(=O)(=O)NCC(=O)N2CCC[C@H]2C(=O)N[C@@H](CCCCN)C(=O)Nc3ccc(cc3)[N+]([O-])=O
InChI
1S/C26H34N6O7S.C2H4O2/c1-18-7-13-21(14-8-18)40(38,39)28-17-24(33)31-16-4-6-23(31)26(35)30-22(5-2-3-15-27)25(34)29-19-9-11-20(12-10-19)32(36)37;1-2(3)4/h7-14,22-23,28H,2-6,15-17,27H2,1H3,(H,29,34)(H,30,35);1H3,(H,3,4)/t22-,23-;/m0./s1
InChI key
KPGSNEYSJPIZCW-SJEIDVEUSA-N
General description
纤溶酶的发色底物。
Application
N-对甲苯磺酰基-甘氨酰-脯氨酰-赖氨酰-4-硝基苯胺乙酸盐已被用于：
- 作为aprE2、aprE5-41的酰胺水解活性检测的底物
- 作为丝氨酸蛋白酶和纤维蛋白原水解测定的底物
- 作为纤溶酶测定的底物
Biochem/physiol Actions
N-对甲苯磺酰基-甘氨酰-脯氨酰-赖氨酰-4-硝基苯胺乙酸盐是纤溶酶测定、丝氨酸蛋白酶活性和纤维蛋白原水解测定的显色底物。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Streptococcus pneumoniae choline-binding protein E interaction with plasminogen/plasmin stimulates migration across the extracellular matrix.
Attali C, et al.
Infection and Immunity, 76(2), 466-476 (2008)
Overexpression of aprE2, a Fibrinolytic Enzyme Gene from Bacillus subtilis CH3-5, in Escherichia coli and the Properties of AprE2.
Jeong SJ, et al.
Journal of microbiology and biotechnology, 24(7), 969-978 (2014)
Min Wang et al.
International journal of biological macromolecules, 146, 781-789 (2019-11-16)
The heterologous nature of SAK, a thrombolytic drug, elicits high titers of neutralizing antibodies, which limits its clinical use. Here, we aim to establish a SAK mutant with equivalent activity to the wild type but reduced antigenicity, which may allow
A bi-functional anti-thrombosis protein containing both direct-acting fibrin (ogen) olytic and plasminogen-activating activities
Yang H, et al.
PLoS ONE, 6(3), e17519-e17519 (2011)
Michał Śmiga et al.
BMC microbiology, 19(1), 127-127 (2019-06-13)
Porphyromonas gingivalis is considered a keystone pathogen responsible for chronic periodontitis. Although several virulence factors produced by this bacterium are quite well characterized, very little is known about regulatory mechanisms that allow different strains of P. gingivalis to efficiently survive
相关内容
Product Information Sheet
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| T6140-25MG | 04061832918594 |
| T6140-5MG | 04061837358401 |
| T6140-10MG | 04061832918587 |
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