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Merck
CN

W1770

WR99210

别名:

1,6-二氢-6,6-二甲基-1-[3-（2,4,5-三氯苯氧基）丙氧基]-1,3,5-三嗪-2,4-二胺

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关于此项目

经验公式（希尔记法）:
C14H18Cl3N5O2
化学文摘社编号:
47326-86-3
分子量:
394.68
NACRES:
NA.77
PubChem Substance ID:
329830427
UNSPSC Code:
12352202
MDL number:
MFCD01679034
Assay:
≥98% (HPLC)
Form:
powder

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assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

DMSO: 0.2 mg/mL, clear (warmed)

storage temp.

2-8°C

SMILES string

CC1(C)N=C(N)N=C(N)N1OCCCOc2cc(Cl)c(Cl)cc2Cl

InChI

1S/C14H18Cl3N5O2/c1-14(2)21-12(18)20-13(19)22(14)24-5-3-4-23-11-7-9(16)8(15)6-10(11)17/h6-7H,3-5H2,1-2H3,(H4,18,19,20,21)

InChI key

MJZJYWCQPMNPRM-UHFFFAOYSA-N

Biochem/physiol Actions

WR99210 是恶性疟原虫二氢叶酸还原酶 (DHFR) 的强效抑制剂，DHFR 是主要的疟疾药物靶点。它对野生型、双突变型和四突变型二氢叶酸还原酶具有亚纳摩尔级的效价。
二氢叶酸还原酶 (DHFR) 抑制剂。

wgk

WGK 3

存储类别

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000042122
0000042125
0000014239
095M4622V
063M4623V

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T F de Koning-Ward et al.
Molecular and biochemical parasitology, 117(2), 155-160 (2001-10-19)
The limited number of selectable markers available for malaria transfection has hindered extensive manipulation of the Plasmodium falciparum genome and subsequently thorough genetic analysis of this organism. In this paper, we demonstrate that P. falciparum is highly sensitive to the
S Mookherjee et al.
The American journal of tropical medicine and hygiene, 61(1), 131-140 (1999-08-04)
As resistance to chloroquine spreads in sub-Saharan Africa, pyrimethamine plus sulfadoxine (PSD) is increasingly used as a first-line treatment for falciparum malaria. Populations of Plasmodium falciparum (Pf) resistant to PSD have been selected quickly in other regions. The resistance is
Manoj Kumar et al.
Molecular diversity, 14(3), 595-604 (2009-08-22)
The worldwide TB structural genomics initiative has identified several new drug targets for Mycobacterium tuberculosis (M. tb). Dihydrofolate reductase (DHFR) catalyzes the NADPH-dependent reduction of dihydrofolate to tetrahydrofolate that is essential for DNA synthesis. Inhibition of its activity leads to
Reinaldo Teixeira Delfino et al.
Biophysical chemistry, 98(3), 287-300 (2002-07-20)
The development of drug resistance is reducing the efficiency of antifolates as antimalarials. This phenomenon has been linked to the occurrence of mutations in the parasite's dihydrofolate reductase (DHFR). In this way, the resistance to pyrimethamine and cycloguanil, two potent
E G Hankins et al.
Molecular and biochemical parasitology, 117(1), 91-102 (2001-09-12)
We have expressed dhfr alleles of Plasmodium falciparum in the budding yeast, Saccharomyces cerevisiae, and used this yeast model to identify single amino acid substitutions that confer high level pyrimethamine resistance on the background of the triple mutant dhfr (I51+R59+N108).
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全球贸易项目编号

货号GTIN
W1770-25MG04061832639604
W1770-5MG04061837488719

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