material
clear polystyrene , clear wells
sterility
sterile
feature
lid
packaging
pkg of 5 ea
manufacturer/tradename
Advanced Pharmaceutical Sciences 71034
size
24 wells
working volume
300 μL
color
clear
suitability
suitable for (suitable for multiple organ co-culture)
binding type
Collagen I coated surface
正在寻找类似产品? 访问 产品对比指南
General description
IdMOC plates are a novel In Vitro System for routine screening of ADMET drug properties.
In previous in vitro systems, each cell type was studied in isolation, ignoring critical interactions between organs when metabolizing drugs. This led to the possibility of many factors such as inter-organ toxicity going unrecognized in drug evaluations. The IdMOC models in vivo multiple-organ interaction, thus allowing the evaluation of organ-specific effects of a drug and its metabolites. The IdMOC consists of multiple, inner wells within a larger interconnecting chamber. Multiple cell types are first individually cultured in the inner wells in media optimized for each cell type.
On the day of experimentation, the individual media are removed and the chamber is filled with a single universal medium, flooding the inner wells and allowing well-to-well communication via the overlying medium. The test material is then added to the overlying medium. After experimentation, the overlying medium can be analyzed for overall metabolism of the test material, and individual cell types can be processed for the quantification of associated test material to evaluate possible organ-specific bioaccumulation, evaluation of cell viability for cytotoxicity, and efficacy.
Applications:
In previous in vitro systems, each cell type was studied in isolation, ignoring critical interactions between organs when metabolizing drugs. This led to the possibility of many factors such as inter-organ toxicity going unrecognized in drug evaluations. The IdMOC models in vivo multiple-organ interaction, thus allowing the evaluation of organ-specific effects of a drug and its metabolites. The IdMOC consists of multiple, inner wells within a larger interconnecting chamber. Multiple cell types are first individually cultured in the inner wells in media optimized for each cell type.
On the day of experimentation, the individual media are removed and the chamber is filled with a single universal medium, flooding the inner wells and allowing well-to-well communication via the overlying medium. The test material is then added to the overlying medium. After experimentation, the overlying medium can be analyzed for overall metabolism of the test material, and individual cell types can be processed for the quantification of associated test material to evaluate possible organ-specific bioaccumulation, evaluation of cell viability for cytotoxicity, and efficacy.
Applications:
- Efficacy: Evaluation of the desired on-target and off-target effects via the examination of pharmacological effects of a drug in cells from target organs as well as off-target organs
- Drug distribution: Estimation of the potential differential drug distribution in multiple organs via the quantification of drugs in cells from multiple organs after exposure
- Drug metabolism: Drug stability and metabolite formation after metabolism by cells from multiple organs
- Drug toxicity: Simultaneous evaluation of toxic potential of a drug on cells from multiple organs under identical experimental conditions
Legal Information
IdMOC is a registered trademark of Advanced Pharmaceutical Sciences, Inc.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
新产品
此项目有
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持