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Merck
CN

A0401

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

别名:

ACTH4-10

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关于此项目

经验公式（希尔记法）:
C44H59N13O10S
化学文摘社编号:
4037-01-8
分子量:
962.09
UNSPSC Code:
12352202
PubChem Substance ID:
24890423
NACRES:
NA.26
MDL number:
MFCD00167482

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产品名称

Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)

SMILES string

CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O

InChI

1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

InChI key

HAAUASBAIUJHAN-UHFFFAOYSA-N

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189, P47866

storage temp.

−20°C

Gene Information

human ... POMC(5443)
rat ... Crhr2(64680)

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.
Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

Lacks adrenocorticotropic activity.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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分析证书(COA)

Lot/Batch Number
BCBR4975V
BCBH4677V
BCBB5783V
BCBB5783
BCBB0110

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The active sequence in the ACTH molecule responsible for inhibition of the extinction of conditioned avoidance behaviour in rats.
H M Greven et al.
European journal of pharmacology, 2(1), 14-16 (1967-10-01)
Heiko Krude et al.
The Journal of clinical endocrinology and metabolism, 88(10), 4633-4640 (2003-10-15)
The symptoms of severe early-onset obesity, adrenal insufficiency, and red hair define the proopiomelanocortin (POMC) deficiency syndrome as described so far in two children with complete loss-of-function mutations of the human POMC gene. In POMC deficiency, obesity reflects the lack
Manfred Hallschmid et al.
The Journal of clinical endocrinology and metabolism, 91(2), 522-525 (2005-12-01)
By enhancing energy expenditure and suppressing appetite, melanocortin peptides derived from proopiomelanocortin play a primary role in the hypothalamic regulation of body weight. In a recent study in normal-weight adults, the 6-wk intranasal administration of the MSH/ACTH(4-10) core fragment of
Neonatal administration of ACTH4-10 and its analog Semax to young laboratory mice modulates the number of catecholaminergic neurons in adult animal diencephalon.
O S Boyarshinova et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 396, 181-183 (2004-09-10)
Sniffing neuropeptides: a transnasal approach to the human brain.
Jan Born et al.
Nature neuroscience, 5(6), 514-516 (2002-05-07)
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