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Merck
CN

A0401

Sigma-Aldrich

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

别名:

ACTH4-10

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关于此项目

经验公式（希尔记法）:
C44H59N13O10S
化学文摘社编号:
4037-01-8
分子量:
962.09
MDL编号:
MFCD00167482
UNSPSC代码:
12352202
PubChem化学物质编号:
24890423
NACRES:
NA.26

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产品名称

Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)

方案

≥97% (HPLC)

表单

powder

颜色

white

UniProt登记号

P01189
P47866

储存温度

−20°C

SMILES字符串

CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O

InChI

1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

InChI key

HAAUASBAIUJHAN-UHFFFAOYSA-N

基因信息

human ... POMC(5443)
rat ... Crhr2(64680)

Amino Acid Sequence

Met-Glu-His-Phe-Arg-Trp-Gly

生化/生理作用

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.
Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

包装

Bottomless glass bottle. Contents are inside inserted fused cone.

分析说明

Lacks adrenocorticotropic activity.

其他说明

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

法规信息

新产品
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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBR4975V
BCBH4677V
BCBB5783V
BCBB5783
BCBB0110

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Bela Juhasz et al.
Antioxidants & redox signaling, 9(11), 1851-1861 (2007-08-25)
The aim of our study was to investigate the contribution of the adrenocorticotropic hormone fragment, ACTH (4-10), on the recovery of postischemic cardiac function. Effects of ACTH (4-10) on caspase-3 activity, cardiomyocyte and endothelial apoptosis, and HO-1 protein expression were
Kun Wang et al.
International immunopharmacology, 87, 106769-106769 (2020-07-19)
In the present study, we aimed to assess whether adrenocorticotropic hormone (ACTH) could protect the podocytes from adriamycin (ADR)-induced injury by stimulating B lymphocytes to secrete the associated cytokines. Proliferation assay was used to assess the proliferation and activity of
Manfred Hallschmid et al.
The Journal of clinical endocrinology and metabolism, 91(2), 522-525 (2005-12-01)
By enhancing energy expenditure and suppressing appetite, melanocortin peptides derived from proopiomelanocortin play a primary role in the hypothalamic regulation of body weight. In a recent study in normal-weight adults, the 6-wk intranasal administration of the MSH/ACTH(4-10) core fragment of
Heiko Krude et al.
The Journal of clinical endocrinology and metabolism, 88(10), 4633-4640 (2003-10-15)
The symptoms of severe early-onset obesity, adrenal insufficiency, and red hair define the proopiomelanocortin (POMC) deficiency syndrome as described so far in two children with complete loss-of-function mutations of the human POMC gene. In POMC deficiency, obesity reflects the lack
The active sequence in the ACTH molecule responsible for inhibition of the extinction of conditioned avoidance behaviour in rats.
H M Greven et al.
European journal of pharmacology, 2(1), 14-16 (1967-10-01)
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