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A0401

Adrenocorticotropic Hormone Fragment 4-10 human, rat

≥97% (HPLC)

别名:

ACTH4-10

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关于此项目

经验公式（希尔记法）:
C44H59N13O10S
化学文摘社编号:
4037-01-8
分子量:
962.09
UNSPSC Code:
12352202
PubChem Substance ID:
24890423
NACRES:
NA.26
MDL number:
MFCD00167482
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产品名称

Adrenocorticotropic Hormone Fragment 4-10 human, rat, ≥97% (HPLC)

assay

≥97% (HPLC)

form

powder

color

white

UniProt accession no.

P01189, P47866

storage temp.

−20°C

SMILES string

CSCCC(N)C(=O)NC(CCC(O)=O)C(=O)NC(Cc1cnc[nH]1)C(=O)NC(Cc2ccccc2)C(=O)NC(CCCNC(N)=N)C(=O)NC(Cc3c[nH]c4ccccc34)C(=O)NCC(O)=O

InChI

1S/C44H59N13O10S/c1-68-17-15-29(45)38(62)53-32(13-14-36(58)59)41(65)57-35(20-27-22-48-24-52-27)43(67)55-33(18-25-8-3-2-4-9-25)42(66)54-31(12-7-16-49-44(46)47)40(64)56-34(39(63)51-23-37(60)61)19-26-21-50-30-11-6-5-10-28(26)30/h2-6,8-11,21-22,24,29,31-35,50H,7,12-20,23,45H2,1H3,(H,48,52)(H,51,63)(H,53,62)(H,54,66)(H,55,67)(H,56,64)(H,57,65)(H,58,59)(H,60,61)(H4,46,47,49)

InChI key

HAAUASBAIUJHAN-UHFFFAOYSA-N

Gene Information

human ... POMC(5443)
rat ... Crhr2(64680)

Biochem/physiol Actions

Adrenocorticotropic Hormone Fragment 4-10 (ACTH (4-10)) attenuates ischemia/reperfusion-induced cardiac injury via reduction in infarct size, caspase 3 activity, and apoptosis, and an increase in HO-1 expression. ACTH 4-10 is a melanocortin 4 receptor (MCR-4) agonist. ACTH 4-10 facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval. ACTH 4-10 and semax are analogues.
Adrenocorticotropic Hormone Fragment 4-10 [ACTH(4-10)], a melanocortin fragment, is used together with its analogue semax to study the processes of nociception/pain sensation and brain development. ACTH(4-10) is also used as a possible anorexic factor. It facilitates active and passive avoidance acquisition, improves short term memory consolidation, and promotes memory retrieval.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Analysis Note

Lacks adrenocorticotropic activity.

Other Notes

Core fragment of ACTH, α- and β-MSH, and β-lipotropin

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

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历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
BCBR4975V
BCBH4677V
BCBB5783V
BCBB5783
BCBB0110

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Yu A Zolotarev et al.
Amino acids, 30(4), 403-408 (2006-06-15)
Here a new approach of the elucidation of paths of proteolytic biodegradation of physiologically active peptides, based on the use of a peptide with isotopic label at all amino acid residues and the enrichment of HPLC samples with unlabeled peptide
D M Ivanova et al.
Bulletin of experimental biology and medicine, 143(1), 5-8 (2007-11-21)
The effects of ACTH4-10 fragment and its analog semax on nociception were examined on various animal models. ACTH4-10 in a dose of 0.5 mg/kg decreased nociception in rats during hindpaw compression test and in mice subjected to acetic acid writhing
Effects of Semax, a peptide ACTH4-10 analogue, on the respiratory burst in human neutrophils.
E I Astashkin et al.
Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 378, 280-282 (2003-08-16)
Manfred Hallschmid et al.
Regulatory peptides, 149(1-3), 79-83 (2008-04-30)
The nose provides an effective way for delivering neuropeptides to the central nervous system, bypassing the blood-brain barrier and avoiding systemic side effects. Thereby intranasal neuropeptide administration enables the modulation of central nervous signaling pathways of body weight regulation and
Claire L Price et al.
Diabetes, 53(6), 1452-1458 (2004-05-27)
Advanced glycation end products (AGEs), a complex and heterogeneous group of posttranslational modifications of proteins in vivo, have been widely studied for their involvement in diabetic complications; these complications are largely vascular and accompanied by inflammation. Because dendritic cells (DCs)
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货号GTIN
A0401-.5MG04061834904885
A0401-5MG04061832818733
A0401-1MG04061826282625

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