A0637
DL-2-氨基己二酸
≥99% (TLC), powder, gliotoxic
别名:
DL-α氨基己二酸
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关于此项目
线性分子式:
HO2C(CH2)3CH(NH2)CO2H
化学文摘社编号:
分子量:
161.16
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
208-809-2
MDL number:
产品名称
DL-2-氨基己二酸, ≥99%
Quality Level
storage temp.
2-8°C
InChI key
OYIFNHCXNCRBQI-UHFFFAOYSA-N
InChI
1S/C6H11NO4/c7-4(6(10)11)2-1-3-5(8)9/h4H,1-3,7H2,(H,8,9)(H,10,11)
SMILES string
NC(CCCC(O)=O)C(O)=O
assay
≥99%
form
powder
mp
196-198 °C (lit.)
Gene Information
rat ... Grin2b(24410)
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Application
DL-2-氨基己二酸（AAA）已被用作一种astrotoxin 毒素，用于杀死可阻止移植的细胞有效整合到视网膜中的星形胶质细胞。它还被用作胶质毒素来研究星形胶质细胞膨胀对弯曲度的影响。
Biochem/physiol Actions
DL-2-氨基己二酸（AAA）是谷氨酸盐的六碳同系物和胶质毒性化合物。它通常用于显著减少小脑培养物中的星形胶质细胞数目，该培养物可用作研究a-氨基己二酸诱导的神经胶质毒性机制的模型。
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Bhagyalaxmi S Ganesh et al.
PloS one, 6(3), e18305-e18305 (2011-04-13)
Reactive gliosis is a hallmark of many retinal neurodegenerative conditions, including glaucoma. Although a majority of studies to date have concentrated on reactive gliosis in the optic nerve head, very few studies have been initiated to investigate the role of
Saadet Mercimek-Mahmutoglu et al.
Pediatrics, 129(5), e1368-e1372 (2012-04-25)
Pyridoxine-dependent epilepsy (PDE) was first described in 1954. The ALDH7A1 gene mutations resulting in α-aminoadipic semialdehyde dehydrogenase deficiency as a cause of PDE was identified only in 2005. Neonatal epileptic encephalopathy is the presenting feature in >50% of patients with
H Bräuner-Osborne et al.
Journal of medicinal chemistry, 39(16), 3188-3194 (1996-08-02)
The homologous series of acidic amino acids, ranging from aspartic acid (1) to 2-aminosuberic acid (5), and the corresponding series of 3-isoxazolol bioisosteres of these amino acids, ranging from (RS)-2-amino-2-(3-hydroxy-5-methylisoxazol-4-yl)acetic acid (AMAA, 6) to (RS)-2-amino-6-(3-hydroxy-5-methylisoxazol-4-yl)hexanoic acid (10), were tested as
Gliotoxic effects of $\alpha$-aminoadipic acid on monolayer cultures of dissociated postnatal mouse cerebellum
Huck S, et al.
Neuroscience, 12(3), 783-791 (1984)
Gliotoxin-induced swelling of astrocytes hinders diffusion in brain extracellular space via formation of dead-space microdomains
Sherpa AD, et al.
Glia, 62(7), 1053-1065 (2014)
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