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A1221

AH6809

Name: AH6809
Brand: SIGMA

≥98%, crystalline solid or supercooled liquid

别名:

6-Isopropoxy-9-oxoxanthene-2-carboxylic acid

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About This Item

经验公式（希尔记法）:

C₁₇H₁₄O₅

CAS Number:

33458-93-4

分子量:

298.29

MDL编号:

MFCD08056083

UNSPSC代码:

12352200

PubChem化学物质编号:

329770690

NACRES:

NA.77

质量水平

100

方案

≥98%

表单

crystalline solid or supercooled liquid

溶解性

ethanol: soluble 2.5 mg/mL
DMSO or DMF: soluble 8 mg/mL

SMILES字符串

CC(C)Oc1ccc2c(Oc3ccc(cc3C2=O)C(O)=O)c1

InChI

1S/C17H14O5/c1-9(2)21-11-4-5-12-15(8-11)22-14-6-3-10(17(19)20)7-13(14)16(12)18/h3-9H,1-2H3,(H,19,20)

InChI key

AQFFXPQJLZFABJ-UHFFFAOYSA-N

应用

AH6809 has been used:

as a prostaglandin E2 receptor 1 & 2 (EP1/2) antagonist to analyze its effects on cyclooxygenase-2 /prostaglandin E2 (COX-2/PGE2) signaling in the angiogenic feedback of endothelial cells to hypoxia
as an EP2 antagonist to study its effects on tumor angiogenesis in human prostate cancer cell lines
as an EP2 antagonist to analyze its effects on overexpression of amyloid precursor protein (APP)

生化/生理作用

AH6809 plays a role in antagonizing the proliferation of non-small cell lung cancer cell lines.

DP/EP prostanoid receptor antagonist; has the highest affinity for DP receptors, but also acts as a weak antagonist at murine EP₁ and EP₂ prostanoid receptors.

特点和优势

This compound is featured on the Prostanoid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

储存分类代码

11 - Combustible Solids

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Gloves, type N95 (US)

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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