form
powder
InChI key
AHTFMWCHTGEJHA-UHFFFAOYSA-N
InChI
1S/C6H6O4S/c1-3(7)11-4-2-5(8)10-6(4)9/h4H,2H2,1H3
SMILES string
CC(=O)SC1CC(=O)OC1=O
assay
≥98%
mp
83-86 °C (lit.)
solubility
acetone: 100 mg/mL, DMF: soluble
storage temp.
−20°C
Application
Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, coupled initially to molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with .05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
Other Notes
Note that the anydride is very reactive and less stable in aqeuous buffer than ester derivative. In addition, this reagent will replace positive amine charge with negative carboxyl.
法规信息
新产品
此项目有
Introduction of sulfhydryl groups into proteins using acetylmercaptosuccinic anhydride.
I M KLOTZ et al.
Archives of biochemistry and biophysics, 96, 605-612 (1962-03-01)
E S Rector et al.
Journal of immunological methods, 24(3-4), 321-336 (1978-01-01)
A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reaction of alkyl halide and sulfhydryl groups, which have been grafted, respectively
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持