方案
≥98%
表单
powder
mp
83-86 °C (lit.)
溶解性
acetone: 100 mg/mL
DMF: soluble
储存温度
−20°C
SMILES字符串
CC(=O)SC1CC(=O)OC1=O
InChI
1S/C6H6O4S/c1-3(7)11-4-2-5(8)10-6(4)9/h4H,2H2,1H3
InChI key
AHTFMWCHTGEJHA-UHFFFAOYSA-N
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应用
Thiolating reagent for primary amines; thiol can be deprotected under mild conditions. Typically, coupled initially to molecule containing primary amine by amide bond buffered at pH 7.5. Deprotection may be accomplished with .05 M hydroxylamine at neutral pH. Useful for preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.
其他说明
Note that the anydride is very reactive and less stable in aqeuous buffer than ester derivative. In addition, this reagent will replace positive amine charge with negative carboxyl.
法规信息
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Introduction of sulfhydryl groups into proteins using acetylmercaptosuccinic anhydride.
I M KLOTZ et al.
Archives of biochemistry and biophysics, 96, 605-612 (1962-03-01)
E S Rector et al.
Journal of immunological methods, 24(3-4), 321-336 (1978-01-01)
A novel procedure for the synthesis of well-defined protein-protein conjugates is described using ovalbumin (OA) and IgG as test proteins. This procedure involves the highly selective and rapid reaction of alkyl halide and sulfhydryl groups, which have been grafted, respectively
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