A1439
垂体腺苷酸环化酶激活多肽-38
别名:
PACAP-38
Amino Acid Sequence
His-Ser-Asp-Gly-Ile-Phe-Thr-Asp-Ser-Tyr-Ser-Arg-Tyr-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Ala-Ala-Val-Leu-Gly-Lys-Arg-Tyr-Lys-Gln-Arg-Val-Lys-Asn-Lys-NH2
一般描述
垂体腺苷酸环化酶激活多肽38（PACAP38）定位于人类染色体18。27个残基的酰胺化片段（PACAP27）包含另一个同种型。PACAP38是与哺乳动物有关的主要同种型。
应用
垂体腺苷酸环化酶激活多肽38已用于测试其在刺激鸡的环状AMP下丘脑和大脑皮质切片形成中的作用，并在细胞迁移试验（cell migration assay）中处理胶质母细胞瘤细胞（U87MG）以测试其抗侵袭作用。
生化/生理作用
PACAP-38 是一种与血管活性肠肽 (VIP) 具有高度同源性的神经肽。 据报道，它是一种神经元存活因子。
垂体腺苷酸环化酶激活多肽38（PACAP38）是一种心脏保护剂，可有助于治疗放射诱发心脏病（RIHD）。它在心肌细胞的氧化应激过程中起保护作用。PACAP38具有抗氧化、抗细胞凋亡和抗炎特性。它与偏头痛和丛集性头痛的病理生理学有关。
其他说明
从0.1％TFA水溶液中冻干
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
J Kinhult et al.
The European respiratory journal, 15(2), 243-247 (2000-03-08)
Pituitary adenylate cyclase-activating peptide (PACAP) 38 displays several biological activities relevant to obstructive airway disease. In this study, the occurrence of PACAP 38 in human small bronchi and corresponding pulmonary arteries was analysed immunocytochemically. The dilatory effects of this peptide
Eloisa Rubio-Beltrán et al.
The journal of headache and pain, 19(1), 64-64 (2018-08-09)
Pituitary adenylate cyclase activating polypeptide-38 (PACAP38) is a widely distributed neuropeptide involved in neuroprotection, neurodevelopment, nociception and inflammation. Moreover, PACAP38 is a potent inducer of migraine-like attacks, but the mechanism behind this has not been fully elucidated.Migraine is a neurovascular
T Dickinson et al.
Neuropharmacology, 38(1), 167-180 (1999-04-08)
Peripheral nerve damage often results in the development of chronic pain states, resistant to classical analgesics. Since vasoactive intestinal polypeptide (VIP) and pituitary adenylate cyclase-activating polypeptide (PACAP) are up-regulated in dorsal root ganglion cells following peripheral nerve injury, we investigated
L M E Pettersson et al.
The European journal of neuroscience, 20(7), 1838-1848 (2004-09-24)
In the present study, expression of pituitary adenylate cyclase-activating polypeptide (PACAP) in rat dorsal root ganglion (DRG) neurons and sciatic nerve following experimental sciatic nerve compression was studied with the use of quantitative immunohistochemistry and in situ hybridization. Previously, we
Grazia Maugeri et al.
Biomedicines, 9(8) (2021-08-28)
Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts different effects in various human cancer. In glioblastoma (GBM), PACAP has been shown to interfere with the hypoxic micro-environment through the modulation of hypoxia-inducible factors via PI3K/AKT and MAPK/ERK pathways inhibition. Considering that hypoxic
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