A1765
乙酰辅酶A合成酶 来源于面包酵母（酿酒酵母）
lyophilized powder, ≥3 units/mg protein
别名:
乙酸硫激酶, 醋酸CoA连接酶（AMP形成）
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关于此项目
化学文摘社编号:
UNSPSC Code:
12352204
NACRES:
NA.26
EC Number:
232-729-7
MDL number:
Specific activity:
≥3 units/mg protein
Application
S-乙酰辅酶 A 合成酶可用于研究各种代谢途径，例如糖酵解、糖异生、丙酮酸代谢和 CO2 固定。它也可以用于基因表达研究。
来自面包酵母的 S-乙酰辅酶 A 合成酶已用于合成 5′-磷酸四磷酸腺苷和 5′-磷酸五磷酸腺苷。
Biochem/physiol Actions
乙酰辅酶 A 合成酶催化乙酰辅酶 A 的产生。它参与细胞核中的组蛋白乙酰化。它可能参与不可发酵碳源（如甘油）的生长。乙酰辅酶 A 合成酶是由乙酸盐、乙醛和乙醇诱导的。
Other Notes
在 37°C，pH 7.5 下，一个单位每分钟将从乙酸盐、ATP 和辅酶 A 生成 1.0 μ 摩尔 S-乙酰辅酶 A。
Packaging
包装尺寸基于蛋白质含量。
Physical form
冻干粉末，含有稳定剂，如磷酸钾、蔗糖和还原型谷胱甘肽
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
存储类别
11 - Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
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Guillaume Baptist et al.
Nucleic acids research, 41(17), e164-e164 (2013-07-31)
We have developed a new screening methodology for identifying all genes that control the expression of a target gene through genetic or metabolic interactions. The screen combines mutant libraries with luciferase reporter constructs, whose expression can be monitored in vivo
Hua Xu et al.
Biochemistry, 50(26), 5883-5892 (2011-06-02)
Recent proteomics studies have revealed that protein acetylation is an abundant and evolutionarily conserved post-translational modification from prokaryotes to eukaryotes. Although an astonishing number of acetylated proteins have been identified in those studies, the acetyltransferases that target these proteins remain
Sandy Thao et al.
mBio, 2(5), doi:10-doi:10 (2011-10-20)
In the bacterium Salmonella enterica, the CobB sirtuin protein deacetylase and the Gcn5-related N(ε)-acetyltransferase (GNAT) Pat control carbon utilization and metabolic flux via N(ε)-lysine acetylation/deacetylation of metabolic enzymes. To date, the S. enterica Pat (SePat) acetyltransferase has not been biochemically
Heidi A Crosby et al.
The Journal of biological chemistry, 287(19), 15590-15601 (2012-03-15)
N-lysine acetylation is a posttranslational modification that has been well studied in eukaryotes and is likely widespread in prokaryotes as well. The central metabolic enzyme acetyl-CoA synthetase is regulated in both bacteria and eukaryotes by acetylation of a conserved lysine
Hidekazu Takahashi et al.
Molecular cell, 23(2), 207-217 (2006-07-22)
Metabolic enzymes rarely regulate informational processes like gene expression. Yeast acetyl-CoA synthetases (Acs1p and 2p) are exceptional, as they are important not only for carbon metabolism but also are shown here to supply the acetyl-CoA for histone acetylation by histone
商品
Enzyme Reagent Coenzyme A (CoA, CoASH or HSCoA) is the key cofactor in first step of the TCA cycle, responsible for transferring the acetyl group from pyruvate oxidation to oxaloacetate yielding citrate. Available through Sigma-Aldrich online.
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