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Merck
CN

A2024

Sigma-Aldrich

阿普拉霉素 硫酸盐

别名:

Nebramycin II

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关于此项目

经验公式（希尔记法）:
C21H41N5O11 · xH2SO4
CAS Number:
65710-07-8
分子量:
539.58 (free base basis)
EC 号:
265-890-7
MDL编号:
MFCD06200257
UNSPSC代码:
51281633
PubChem化学物质编号:
329770728
NACRES:
NA.85

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生物来源

Streptomyces tenebrarius

质量水平

200

表单

powder

颜色

white to brown

抗生素抗菌谱

Gram-negative bacteria

作用机制

protein synthesis | interferes

储存温度

2-8°C

SMILES字符串

OS(O)(=O)=O.CN[C@H]1[C@@H](O)[C@H]2O[C@H](O[C@@H]3[C@@H](N)C[C@@H](N)[C@H](O)[C@H]3O)[C@H](N)C[C@@H]2O[C@@H]1O[C@H]4O[C@H](CO)[C@@H](N)[C@H](O)[C@H]4O

InChI

1S/C21H41N5O11.H2O4S/c1-26-11-14(30)18-8(33-20(11)37-21-16(32)13(29)10(25)9(4-27)34-21)3-7(24)19(36-18)35-17-6(23)2-5(22)12(28)15(17)31;1-5(2,3)4/h5-21,26-32H,2-4,22-25H2,1H3;(H2,1,2,3,4)/t5-,6+,7-,8+,9-,10-,11+,12+,13+,14-,15-,16-,17-,18+,19+,20-,21-;/m1./s1

InChI key

WGLYHYWDYPSNPF-RQFIXDHTSA-N

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一般描述

化学结构：氨基糖苷类

应用

阿霉素用于研究细菌和原核生物的抗生素耐药性以及蛋白质合成易位步骤抑制。

生化/生理作用

阿霉素通过阻断易位抑制蛋白质合成。它还能结合真核解码位点。在低浓度下，它会抑制延伸和诱导mRNA在蛋白质合成的误读。

包装

1G，5G

其他说明

保存于密闭容器内，置于干燥通风处。请存放在干燥处。储存等级（TRGS 510）：不可燃急性毒性3类/有毒有害物质或引起慢性影响的有害物质。

象形图

Health hazard
GHS08

警示用语：

Danger

危险声明

H360FD

危险分类

Repr. 1B

储存分类代码

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

闪点(°F)

Not applicable

闪点(°C)

Not applicable

个人防护装备

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges, type P3 (EN 143) respirator cartridges

法规信息

监管及禁止进口产品

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
0000430810
0000430810
0000395317
0000356526
0000334301

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Proceedings of the National Academy of Sciences of the United States of America, 109(27), 10984-10989 (2012-06-16)
Aminoglycosides are potent antibacterials, but therapy is compromised by substantial toxicity causing, in particular, irreversible hearing loss. Aminoglycoside ototoxicity occurs both in a sporadic dose-dependent and in a genetically predisposed fashion. We recently have developed a mechanistic concept that postulates
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Antimicrobial agents and chemotherapy, 52(4), 1230-1237 (2008-01-30)
A bioassay was developed to measure the minimum concentration of an antimicrobial drug that disrupts the colonization resistance mediated by model human intestinal microbiota against Salmonella invasion of Caco-2 intestinal cells. The bioassay was used to measure the minimum disruptive
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