A210
(±)-α-Amino-3-carbomethoxy-5-methylisoxazole-4-propanoic acid
crystalline
别名:
(±)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]propionic acid
产品名称
(±)-α-Amino-3-carbomethoxy-5-methylisoxazole-4-propanoic acid, crystalline
SMILES string
Cc1onc(OCC(O)=O)c1CC(N)C(O)=O
form
crystalline
color
white
solubility
H2O: 2.5 mg/mL
storage temp.
2-8°C
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Biochem/physiol Actions
Non-NMDA glutamate receptor antagonist that protects against kainic acid-induced cell damage in vitro.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Berg et al.
Acta neuropathologica, 81(3), 255-260 (1991-01-01)
The possible neuroprotective effects of two new non-N-methyl-D-aspartate receptor antagonists were determined by quantitative light microscopy after intracerebral administration of kainic acid (KA) in two rat brain regions. KA alone or KA in combination with the antagonists alpha-amino-3-carboxy-methoxy-5-methyl-4-isoxazolepropionic acid (AMOA)
A Frandsen et al.
Neurochemical research, 17(1), 35-43 (1992-01-01)
Using cultured cerebral cortical neurons at mature stages (9 days in culture, d.i.c.) it was demonstrated that glutamate, NMDA (N-methyl-D-aspartate) and to a lesser extent KA (kainate) increase the intracellular cGMP concentration ([cGMP]i) whereas no such effect was observed after
P Wahl et al.
Journal of neuroscience research, 33(3), 392-397 (1992-11-01)
Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift to the right of the dose-response
M Lyubkin et al.
Journal of neurophysiology, 78(5), 2475-2482 (1997-11-14)
Interaction between tetanus long-term potentiation and hypoxia-induced potentiation in the rat hippocampus. J. Neurophysiol. 78: 2475-2482, 1997. The interaction between tetanus-induced long-term potentiation (LTP) and hypoxia-induced potentiation was investigated by performing extracellular recordings in the CA1 region of rat hippocampus
A Frandsen et al.
Journal of neurochemistry, 55(5), 1821-1823 (1990-11-01)
The effect on excitatory amino acid (EAA)-induced toxicity of two novel non-N-methyl-D-aspartate (non-NMDA) antagonists 2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionic acid (AMOA) and 2-amino-3-[2-(3-hydroxy-5-methyl-isoxazol-4-yl)methyl-5-methyl-3- oxoisoxazolin-4-yl]propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation
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