A210
(±)-α-Amino-3-carbomethoxy-5-methylisoxazole-4-propanoic acid
crystalline
别名:
(±)-2-Amino-3-[3-(carboxymethoxy)-5-methyl-isoxazol-4-yl]propionic acid
表单
crystalline
颜色
white
溶解性
H2O: 2.5 mg/mL
储存温度
2-8°C
SMILES字符串
Cc1onc(OCC(O)=O)c1CC(N)C(O)=O
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生化/生理作用
Non-NMDA glutamate receptor antagonist that protects against kainic acid-induced cell damage in vitro.
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M Berg et al.
Acta neuropathologica, 81(3), 255-260 (1991-01-01)
The possible neuroprotective effects of two new non-N-methyl-D-aspartate receptor antagonists were determined by quantitative light microscopy after intracerebral administration of kainic acid (KA) in two rat brain regions. KA alone or KA in combination with the antagonists alpha-amino-3-carboxy-methoxy-5-methyl-4-isoxazolepropionic acid (AMOA)
M Lyubkin et al.
Journal of neurophysiology, 78(5), 2475-2482 (1997-11-14)
Interaction between tetanus long-term potentiation and hypoxia-induced potentiation in the rat hippocampus. J. Neurophysiol. 78: 2475-2482, 1997. The interaction between tetanus-induced long-term potentiation (LTP) and hypoxia-induced potentiation was investigated by performing extracellular recordings in the CA1 region of rat hippocampus
A Frandsen et al.
Journal of neurochemistry, 55(5), 1821-1823 (1990-11-01)
The effect on excitatory amino acid (EAA)-induced toxicity of two novel non-N-methyl-D-aspartate (non-NMDA) antagonists 2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionic acid (AMOA) and 2-amino-3-[2-(3-hydroxy-5-methyl-isoxazol-4-yl)methyl-5-methyl-3- oxoisoxazolin-4-yl]propionic acid (AMNH) was tested in primary cultures of cerebral cortex neurons. Such cultures provide a useful model for the investigation
P Wahl et al.
Journal of neuroscience research, 33(3), 392-397 (1992-11-01)
Pharmacological characterization of the action of the novel non-N-methyl-D-aspartate (non-NMDA) antagonist AMOA (2-amino-3-[3-(carboxymethoxy)-5-methylisoxazol-4-yl]propionate) on glutamate receptors was investigated in Xenopus oocytes injected with mouse brain mRNA. AMOA (150 microM) produced a nearly parallel shift to the right of the dose-response
A Frandsen et al.
Neurochemical research, 17(1), 35-43 (1992-01-01)
Using cultured cerebral cortical neurons at mature stages (9 days in culture, d.i.c.) it was demonstrated that glutamate, NMDA (N-methyl-D-aspartate) and to a lesser extent KA (kainate) increase the intracellular cGMP concentration ([cGMP]i) whereas no such effect was observed after
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