A231
花生四烯基三氟甲基酮
oil, ≥97% (NMR)
别名:
1,1,1-三氟甲基-6,9,12,15-heieicosatetraen-2-酮, AACOCF3, Arach-CF3
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关于此项目
经验公式（希尔记法）:
C21H31F3O
CAS Number:
分子量:
356.47
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
质量水平
方案
≥97% (NMR)
表单
oil
储存条件
desiccated
protect from light
under inert gas
颜色
yellow
溶解性
DMSO: >5 mg/mL
储存温度
−20°C
SMILES字符串
CCCCC\C=C/C\C=C/C\C=C/C\C=C/CCCC(=O)C(F)(F)F
InChI
1S/C21H31F3O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-20(25)21(22,23)24/h6-7,9-10,12-13,15-16H,2-5,8,11,14,17-19H2,1H3/b7-6-,10-9-,13-12-,16-15-
InChI key
PLWROONZUDKYKG-DOFZRALJSA-N
基因信息
human ... PLA2G1B(5319)
储存分类代码
10 - Combustible liquids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Backil Sung et al.
Pain, 131(1-2), 121-131 (2007-02-03)
Spinal glutamate transporters (GT) have been implicated in the mechanisms of neuropathic pain; however, how spinal GT uptake activity is regulated remains unclear. Here we show that alteration of spinal arachidonic acid (AA) turnover after peripheral nerve injury regulated regional
Adam C Vana et al.
Experimental neurology, 231(1), 45-55 (2011-06-21)
Inhibition of phospholipase A(2) (PLA(2)) has recently been found to attenuate the pathogenesis of experimental autoimmune encephalomyelitis (EAE), a commonly used animal model of multiple sclerosis (MS). However, the protective mechanisms that underlie PLA(2) inhibition are still not well understood.
B Koutek et al.
The Journal of biological chemistry, 269(37), 22937-22940 (1994-09-16)
Arachidonoyl ethanolamide (anandamide) is a naturally occurring brain constituent that binds to a specific brain cannabinoid receptor (CBR1). An amidase activity (anandamide amidase) in membrane fractions of brain and in cultured neuroblastoma cells rapidly degrades anandamide to arachidonic acid (Deutsch
Arachidonyl trifluoromethyl ketone, a potent inhibitor of 85-kDa phospholipase A2, blocks production of arachidonate and 12-hydroxyeicosatetraenoic acid by calcium ionophore-challenged platelets.
Riendeau D, et al.
The Journal of Biological Chemistry, 269(22), 15619-15624 (1994)
Wen Li et al.
Biochemistry, 47(52), 13997-14008 (2008-12-10)
TCDD (dioxin) induces a rapid inflammatory response from 3T3-L1 adipocytes as judged by prominent induction of the mRNA expression of prostaglandin-endperoxide synthase 2 (Cox-2) along with other inflammation markers within 1 h. This action of TCDD is clearly antagonized by
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