A2327
Adrenomedullin 52 human
≥90% (HPLC), powder
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关于此项目
经验公式（希尔记法）:
C264H406N80O77S3
化学文摘社编号:
分子量:
6028.73
UNSPSC Code:
51111800
NACRES:
NA.32
MDL number:
General description
Adrenomedullin (ADM) human comprises of 52 amino acids and has amine group in the C-terminal tyrosine residue. It also has a N-terminal ring structure and belongs to calcitonin peptide family. ADM has vasodilatory function and is mapped to human chromosome 11p15.4. Adrenomedullin is highly expressed in endothelial cells. Adrenomedullin controls a majority of cellular processes using cyclic adenosine monophosphate (cAMP) as a messenger. It interacts with calcitonin receptor-like receptor (CRLR) and receptor activity modifying protein 2 (RAMP2). ADM contributes to invasion activity in brain tumor cell lines. ADM signalling plays a key role in tumor progression, especially in acute myeloid leukemia.
Application
Adrenomedullin 52 human has been used in tube formation assay in human umbilical vein endothelial cells (HUVECs).
Biochem/physiol Actions
Elicits a potent hypotensive effect; plays a key role in regulating endometrial angiogenesis.
Peptide elicits potent hypotensive effect, comparable to calcitonin gene-related peptide. Plays a key role in regulating endometrial angiogenesis.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
涉药品监管产品
此项目有
Transcriptional regulation of adrenomedullin by oncostatin M in human astroglioma cells: Implications for tumor invasion and migration.
Lim SY, et al.
Scientific Reports, 4(4), 6444-6444 (2014)
Philipp Schuetz et al.
Current opinion in infectious diseases, 26(2), 159-167 (2013-02-26)
In patients with community-acquired pneumonia (CAP), blood biomarkers can help to substantially improve individual decisions involving initiation, (de-)intensification, and cessation of antibiotics, and initial risk stratification, site-of-care assignment (outpatient versus ward versus ICU), and discharge. To illustrate these processes, this
Ben S T Wong et al.
Biology of reproduction, 88(2), 34-34 (2012-12-18)
Extravillous cytotrophoblast (EVCT) is responsible for trophoblast invasion, which is an important process during placentation. Dysregulation of the process is associated with a wide range of pregnancy complications. Adrenomedullin (ADM) is a polypeptide expressed most abundantly in first-trimester placentas. We
A Fedorowski et al.
Journal of internal medicine, 273(4), 359-367 (2013-03-21)
The aim of the study was to investigate the resting levels of novel cardiovascular biomarkers in common types of noncardiac syncope. An observational study was conducted including 255 patients (mean age 60 years, range 15-93; 45% men) with unexplained syncopal
Plasma adrenomedullin level is related to a single nucleotide polymorphism in the adrenomedullin gene.
Cheung BMY, et al.
European Journal of Endocrinology, 165(4), 571-577 (2011)
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