应用
αα2-氨基嘌呤已被用于抑制骨关节炎(OA)软骨细胞的真核起始因子2(eIF2)-磷酸化。
2-氨基嘌呤(2-AP)可用于双链RNA依赖性蛋白激酶、蛋白激酶R(PKR)的特异性抑制。
生化/生理作用
2-氨基嘌呤(2AP)是一种鸟苷和腺苷的类似物,可以与胞嘧啶和胸腺嘧啶碱基配对。它可用作核酸结构和动力学分析的荧光探针。2-氨基嘌呤(2-AP)可抑制双链RNA依赖性蛋白激酶蛋白激酶R(PKR)。
警示用语:
Warning
危险声明
危险分类
Acute Tox. 4 Oral
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
2-Aminopurine.
A Ronen
Mutation research, 75(1), 1-47 (1980-01-01)
Julien Godet et al.
Nucleic acids research, 41(9), 5036-5048 (2013-03-21)
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Bakhos A Tannous et al.
Journal of the National Cancer Institute, 105(17), 1322-1331 (2013-08-14)
Glioblastomas exhibit a high level of chemotherapeutic resistance, including to the antimitotic agents vincristine and taxol. During the mitotic agent-induced arrest, glioblastoma cells are able to perform damage-control and self-repair to continue proliferation. Monopolar spindle 1 (MPS1/TTK) is a checkpoint
Danqing Xin et al.
Brain, behavior, and immunity, 73, 222-234 (2018-05-12)
We previously reported that l-Cysteine, an H2S donor, significantly alleviated brain injury after hypoxia-ischemic (HI) injury in neonatal mice. However, the mechanisms underlying this neuroprotective effect of l-Cysteine against HI insult remain unknown. In the present study, we tested the
Double-Stranded RNA-Dependent Protein Kinase Is Involved in 2-Methoxyestradiol?Mediated Cell Death of Osteosarcoma Cells
Shogren KL, et al.
Journal of Bone and Mineral Research, 22(1), 29-36 (2007)
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