A3539
3-氨基-2,3-二氢苯甲酸 盐酸盐
≥98%
别名:
5-氨基-1,3-环己二烯-1-羧酸 盐酸盐, 格巴库林 盐酸盐
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关于此项目
经验公式（希尔记法）:
C7H9NO2 · HCl
化学文摘社编号:
分子量:
175.61
Beilstein:
4552667
EC 号:
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
方案
≥98%
mp
203 °C (dec.) (lit.)
储存温度
2-8°C
SMILES字符串
Cl[H].NC1CC(=CC=C1)C(O)=O
InChI
1S/C7H9NO2.ClH/c8-6-3-1-2-5(4-6)7(9)10;/h1-3,6H,4,8H2,(H,9,10);1H
InChI key
OBZFLUDUSNCZKL-UHFFFAOYSA-N
基因信息
human ... GABRG1(2565), GABRG2(2566), GABRG3(2567)
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一般描述
γ-aminobutyric acid (GABA) is an inhibitory neurotransmitter that binds selective transmembrane receptors, resulting in gating of ion channels in the central nervous system. GABA that is released from the receptors is degraded by GABA-transaminase. Gabaculine (3-Amino-2,3-dihydrobenzoic acid) is a neurotoxin that was first isolated from Streptomyces toyocaenis and is a conformationally constrained analog of GABA. Gabaculine inhibits GABA-transaminase, which results in an increase of endogenous GABA in the brain and spinal cord.
生化/生理作用
3-Amino-2,3-dihydrobenzoic acid hydrochloride potently and specifically inhibits GABA-transaminase (GABA-T), resulting in inhibited degradation of GABA. May inhibit glutamic acid decarboxylase (GAD), though it is 1000-fold more effective as a GABA-T inhibitor than as a GAD inhibitor.
储存分类代码
13 - Non Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
C Piérard et al.
Experimental brain research, 127(3), 321-327 (1999-08-19)
The aim of this work was to study the neurochemical effects in the brain of GABA-transaminase inhibition by systemic administration of gabaculine (100 mg/kg, i.a.) in the rat. In order to investigate neurotransmitter and related amino-acid compartmentation and metabolism, we
D O'sullivan et al.
The Biochemical journal, 330 ( Pt 2), 627-632 (1998-04-18)
The metabolism of 14C-labelled arginine and ornithine was studied in the isolated, nonrecirculating, perfused rat liver. The catabolism of these amino acids required ornithine aminotransferase since treatment of rats with gabaculine, an inhibitor of this enzyme, decreased substantially the production
Jehoon Yang et al.
Journal of neuroscience methods, 182(2), 236-243 (2009-06-23)
Previous in vivo magnetic resonance spectroscopy (MRS) studies of gamma-aminobutyric acid (GABA) synthesis have relied on (13)C label incorporation into GABA C2 from [1-(13)C] or [1,6-(13)C(2)]glucose. In this study, the [(13)C]GABA C1 signal at 182.3 ppm in the carboxylic/amide spectral
A B Patel et al.
Brain research, 919(2), 207-220 (2001-11-10)
The objective of the present study was to assess the degree to which astrocytic glutamine provides carbon for net synthesis of GABA in the rat neocortex in vivo. Isotopic labeling of GABA and glutamate from astrocytic glutamine was followed in
A S Taisova et al.
Mikrobiologiia, 75(2), 165-171 (2006-06-09)
We determined the concentrations of bacteriochlorophylls (BChl) in the light-harvesting antennae of Oscillochloris trichoides (of the family Oscillochloridaceae belonging to green filamentous mesophilic bacteria) cultivated either with gabaculine, an inhibitor of the C-5 pathway of BChl biosynthesis in a number
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