产品名称
天青蛋白, from Pseudomonas aeruginosa, lyophilized powder
biological source
Pseudomonas aeruginosa
form
lyophilized powder
composition
Protein, ≥65% Lowry
concentration
≥65.0% (Lowry)
technique(s)
toxicology assay: suitable
solubility
water: soluble 1—1.1 mg/mL, clear, blue (light blue to blue)
UniProt accession no.
storage temp.
−20°C
Quality Level
Gene Information
Pseudomonas aeruginosa ... AZU(878046)
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Application
天青素可用于：
- 骨肉瘤细胞系的细胞毒性和细胞活力研究
- 相互作用研究中氮化硅悬臂的功能化
- 氧化硅和云母的金表面和绝缘的功能化氧化物表面的涂层
Biochem/physiol Actions
在细菌反硝化过程中，天青蛋白作为亚硝酸盐还原酶的电子供体。天青蛋白表现出抗癌活性，因为它阻碍了与癌症进展相关的各种独立信号通路。它与肿瘤抑制蛋白p53结合，诱导癌细胞凋亡或阻止癌细胞生长。天青蛋白通过降低VEGFR-2酪氨酸激酶的活性来抑制肿瘤生长，从而破坏血管生成。已经观察到它在人类乳腺癌细胞和人类黑色素瘤细胞中显示出细胞毒性。
天青素是铜氧还蛋白家族中的金属蛋白。它比正常细胞优先进入癌细胞并诱导细胞凋亡。Azurin 与 ephrinB2 结构相似，并且实际上结合了 ephrin 受体酪氨酸激酶 EphB2 来启动参与癌症发展的细胞信号传导。天青素抑制 EphB2 酪氨酸残基的自磷酸化，干扰上游细胞信号传导并有助于抑制癌细胞生长。
General description
研究领域：细胞凋亡。天青蛋白是一种质周蛋白，是同型四聚体。
Physical form
含有醋酸铵缓冲盐的冻干粉末。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
常规特殊物品
此项目有
Wenjie Li et al.
ACS nano, 6(12), 10816-10824 (2012-11-10)
Solid-state electron transport (ETp) via a monolayer of immobilized azurin (Az) was examined by conducting probe atomic force microscopy (CP-AFM), as a function of both temperature (248-373K) and applied tip force (6-15 nN). At low forces, ETp via holo-Az (with
Matthew P McLaughlin et al.
Journal of the American Chemical Society, 134(48), 19746-19757 (2012-11-22)
The apoprotein of Pseudomonas aeruginosa azurin binds iron(II) to give a 1:1 complex, which has been characterized by electronic absorption, Mössbauer, and NMR spectroscopies, as well as X-ray crystallography and quantum-chemical computations. Despite potential competition by water and other coordinating
Daniel Raimunda et al.
Metallomics : integrated biometal science, 5(2), 144-151 (2013-01-29)
Pseudomonas aeruginosa, an opportunistic pathogen, has two transmembrane Cu(+) transport ATPases, CopA1 and CopA2. Both proteins export cytoplasmic Cu(+) into the periplasm and mutation of either gene leads to attenuation of virulence. CopA1 is required for maintaining cytoplasmic copper levels
Leandro Gammuto et al.
Microorganisms, 10(1) (2022-01-22)
Azurin is a bacterial-derived cupredoxin, which is mainly involved in electron transport reactions. Interest in azurin protein has risen in recent years due to its anticancer activity and its possible applications in anticancer therapies. Nevertheless, the attention of the scientific
Krzysztof Kazimierczuk et al.
Journal of magnetic resonance (San Diego, Calif. : 1997), 223, 1-10 (2012-09-11)
The resolution of multidimensional NMR spectra can be severely limited when regular sampling based on the Nyquist-Shannon theorem is used. The theorem binds the sampling rate with a bandwidth of a sampled signal and thus implicitly creates a dependence between
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