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A3672

天青蛋白

Name: 天青蛋白
Brand: SIGMA

from Pseudomonas aeruginosa, lyophilized powder

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关于此项目

化学文摘社编号:

12284-43-4

UNSPSC Code:

12352202

EC Number:

235-551-8

NACRES:

NA.61

MDL number:

MFCD00130594

Form:

lyophilized powder

Biological source:

Pseudomonas aeruginosa

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biological source

Pseudomonas aeruginosa

Quality Level

200

form

lyophilized powder

composition

Protein, ≥65% Lowry

concentration

≥65.0% (Lowry)

technique(s)

toxicology assay: suitable

solubility

water: soluble 1—1.1 mg/mL, clear, blue (light blue to blue)

UniProt accession no.

P00282

storage temp.

−20°C

Gene Information

Pseudomonas aeruginosa ... AZU(878046)

General description

研究领域：细胞凋亡。天青蛋白是一种质周蛋白，是同型四聚体。

Application

天青素可用于：

骨肉瘤细胞系的细胞毒性和细胞活力研究
相互作用研究中氮化硅悬臂的功能化
氧化硅和云母的金表面和绝缘的功能化氧化物表面的涂层

Biochem/physiol Actions

在细菌反硝化过程中，天青蛋白作为亚硝酸盐还原酶的电子供体。天青蛋白表现出抗癌活性，因为它阻碍了与癌症进展相关的各种独立信号通路。它与肿瘤抑制蛋白p53结合，诱导癌细胞凋亡或阻止癌细胞生长。天青蛋白通过降低VEGFR-2酪氨酸激酶的活性来抑制肿瘤生长，从而破坏血管生成。已经观察到它在人类乳腺癌细胞和人类黑色素瘤细胞中显示出细胞毒性。

天青素是铜氧还蛋白家族中的金属蛋白。它比正常细胞优先进入癌细胞并诱导细胞凋亡。Azurin 与 ephrinB2 结构相似，并且实际上结合了 ephrin 受体酪氨酸激酶 EphB2 来启动参与癌症发展的细胞信号传导。天青素抑制 EphB2 酪氨酸残基的自磷酸化，干扰上游细胞信号传导并有助于抑制癌细胞生长。

Physical form

含有醋酸铵缓冲盐的冻干粉末。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

法规信息

常规特殊物品

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历史批次信息供参考:

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Interaction of p53 with Mdm2 and azurin as studied by atomic force spectroscopy

Funari G, et al.

Journal of Molecular Recognition, 23(4), 343-351 (2010)

Density functional study on UV/VIS spectra of copper-protein active sites: the effect of mutations.

Marcel Swart et al.

Chemistry & biodiversity, 9(9), 1728-1738 (2012-09-15)

UV/VIS Electron excitation spectra have been computed for large, realistic model systems of the blue copper protein family. Fully quantum-chemical calculations at the density-functional theory level employing polarized triple-ζ basis sets have been performed on systems of over 120 atoms

Escherichia coli Nissle 1917 targets and restrains mouse B16 melanoma and 4T1 breast tumors through expression of azurin protein.

Yunlei Zhang et al.

Applied and environmental microbiology, 78(21), 7603-7610 (2012-08-28)

Many studies have demonstrated that intravenously administered bacteria can target and proliferate in solid tumors and then quickly be released from other organs. Here, we employed the tumor-targeting property of Escherichia coli Nissle 1917 to inhibit mouse B16 melanoma and

Spectroscopic and DFT studies of second-sphere variants of the type 1 copper site in azurin: covalent and nonlocal electrostatic contributions to reduction potentials.

Ryan G Hadt et al.

Journal of the American Chemical Society, 134(40), 16701-16716 (2012-09-19)

The reduction potentials (E(0)) of type 1 (T1) or blue copper (BC) sites in proteins and enzymes with identical first coordination spheres around the redox active copper ion can vary by ~400 mV. Here, we use a combination of low-temperature

Direct electron transfer from pseudoazurin to nitrous oxide reductase in catalytic N2O reduction.

Koyu Fujita et al.

Journal of inorganic biochemistry, 115, 163-173 (2012-08-23)

Pseudoazurin (PAz), a well-characterized blue copper electron-transfer protein, is shown herein to be capable of mediating electron transfer to the nitrous oxide reductase (N(2)OR) from Achromobacter cycloclastes (Ac). Spectroscopic measurements demonstrate that reduced PAz is efficiently re-oxidized by a catalytic

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货号	GTIN
A3672-1MG	04061826670903

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