A5157
DL-2-Amino-7-phosphonoheptanoic acid
~95%
别名:
AP-7
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关于此项目
经验公式（希尔记法）:
C7H16NO5P
化学文摘社编号:
分子量:
225.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
~95%
SMILES string
NC(CCCCCP(O)(O)=O)C(O)=O
InChI
1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)
InChI key
MYDMWESTDPJANS-UHFFFAOYSA-N
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
rat ... Grin2a(24409), Grin2b(24410)
Biochem/physiol Actions
Selective NMDA glutamate receptor antagonist; anticonvulsant.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
L J Bertoglio et al.
Life sciences, 79(23), 2238-2244 (2006-08-18)
Several neurotransmitters, including GABA, serotonin, glutamate, and cholecystokinin, modulate defensive behaviors in the dorsolateral periaqueductal gray (dlPAG). Although both glutamate and cholecystokinin have been shown to facilitate these behaviors, a possible interaction between them remains to be examined. The present
Daniele Cristina Aguiar et al.
Journal of neuroscience research, 87(11), 2418-2429 (2009-04-11)
Innate fear stimulus induces activation of neurons containing the neuronal nitric oxide synthase enzyme (nNOS) in defensive-related brain regions such as the dorsolateral periaqueductal gray (dlPAG). Intra-dlPAG administration of nitric oxide synthase (NOS) inhibitors and glutamate antagonists induce anxiolytic-like responses.
M Benveniste et al.
British journal of pharmacology, 104(1), 207-221 (1991-09-01)
1. The kinetics of action of 17 structurally related NMDA receptor competitive antagonists were measured under voltage clamp in mouse hippocampal neurones. Analysis of the response to rapid changes in antagonist concentration during constant application of agonist was used to