A5157
DL-2-Amino-7-phosphonoheptanoic acid
~95%
别名:
AP-7
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关于此项目
经验公式（希尔记法）:
C7H16NO5P
化学文摘社编号:
分子量:
225.18
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
assay
~95%
SMILES string
NC(CCCCCP(O)(O)=O)C(O)=O
InChI
1S/C7H16NO5P/c8-6(7(9)10)4-2-1-3-5-14(11,12)13/h6H,1-5,8H2,(H,9,10)(H2,11,12,13)
InChI key
MYDMWESTDPJANS-UHFFFAOYSA-N
Gene Information
human ... GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
rat ... Grin2a(24409), Grin2b(24410)
Biochem/physiol Actions
Selective NMDA glutamate receptor antagonist; anticonvulsant.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
M K Bazil et al.
The American journal of physiology, 260(1 Pt 2), H267-H275 (1991-01-01)
These studies investigated the role of spinal N-methyl-D-aspartic acid (NMDA) receptors in the mediation of cardiovascular responses evoked by L-glutamate (L-Glu) stimulation of the rostral ventrolateral medulla (RVM). Microinjections of L-Glu into the RVM of urethan-anesthetized rats increased mean arterial
L J Bertoglio et al.
Life sciences, 79(23), 2238-2244 (2006-08-18)
Several neurotransmitters, including GABA, serotonin, glutamate, and cholecystokinin, modulate defensive behaviors in the dorsolateral periaqueductal gray (dlPAG). Although both glutamate and cholecystokinin have been shown to facilitate these behaviors, a possible interaction between them remains to be examined. The present
Daniele Cristina Aguiar et al.
Journal of neuroscience research, 87(11), 2418-2429 (2009-04-11)
Innate fear stimulus induces activation of neurons containing the neuronal nitric oxide synthase enzyme (nNOS) in defensive-related brain regions such as the dorsolateral periaqueductal gray (dlPAG). Intra-dlPAG administration of nitric oxide synthase (NOS) inhibitors and glutamate antagonists induce anxiolytic-like responses.