A5513
N-乙酰普鲁卡因胺 盐酸盐
≥99% (HPLC), Class III antiarrhythmic, powder
别名:
N-乙酰普卡胺 盐酸盐, NAPA, 乙酰卡尼 盐酸盐
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关于此项目
线性分子式:
4-(CH3CONH)C6H4CONHCH2CH2N(C2H5)2·HCl
化学文摘社编号:
分子量:
313.82
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352100
EC Number:
251-831-2
MDL number:
Assay:
≥99% (HPLC)
Form:
powder
产品名称
N-乙酰普鲁卡因胺 盐酸盐, ≥99% (HPLC), powder
Quality Segment
assay
≥99% (HPLC)
form
powder
mp
184-186 °C (lit.)
solubility
H2O: 50 mg/mL
storage temp.
−20°C
SMILES string
Cl[H].CCN(CC)CCNC(=O)c1ccc(NC(C)=O)cc1
InChI
1S/C15H23N3O2.ClH/c1-4-18(5-2)11-10-16-15(20)13-6-8-14(9-7-13)17-12(3)19;/h6-9H,4-5,10-11H2,1-3H3,(H,16,20)(H,17,19);1H
InChI key
IYEWBJUCJHKLHD-UHFFFAOYSA-N
Application
N-Acetylprocainamide hydrochloride may be used:
- as an internal standard for spiking plasma samples for ultra-high-pressure liquid chromatography coupled with a diode array detector (UHPLC-DAD) analysis
- to test its relaxant effect on tracheal smooth muscle tissue preparations
- in preparation of complexes with N-acetyl-L-tyrosine methyl ester and N-acetyl-L-phenylalanine methyl ester for studying intermolecular interactions using nuclear magnetic resonance (NMR) spectroscopy studies
N-Acetylprocainamide hydrochloride is a class III antiarrhythmic compound. N-Acetylprocainamide hydrochloride has been used in a study to determine the disposition of procainamide and N-acetylprocainamide in protein-calorie malnutrition. N-Acetylprocainamide hydrochloride has also been used to study pharmacokinetics of procainamide and N-acetylprocainamide in rats.
Biochem/physiol Actions
III 类抗心律失常药。通过降低延时的外向钾电流、稍微降低钙电流以及稍微抑制内向整流钾电流来增大动作电位的持续时间。这是普鲁卡因胺的活性代谢物，不会导致全身性红斑狼疮。
作用于钾电流的 III 类抗心律失常药。
N-acetyltransferase II in liver catalyzes the conversion of procainamide to N-acetylprocainamide (NAPA).
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)