A6226
AM251
>98% (HPLC), solid, cannabinoid receptor (CB1) antagonist
别名:
1-（2,4-二氯苯基）-5-（4-碘苯基）-4-甲基-N-1-哌啶基-1H-吡唑-3-甲酰胺
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关于此项目
经验公式（希尔记法）:
C22H21N4OCl2I
CAS Number:
分子量:
555.24
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
AM251, >98% (HPLC), solid
质量水平
方案
>98% (HPLC)
表单
solid
颜色
white
溶解性
DMSO: >10 mg/mL
H2O: insoluble
创始人
Sanofi Aventis
SMILES字符串
Cc1c(nn(-c2ccc(Cl)cc2Cl)c1-c3ccc(I)cc3)C(=O)NN4CCCCC4
InChI
1S/C22H21Cl2IN4O/c1-14-20(22(30)27-28-11-3-2-4-12-28)26-29(19-10-7-16(23)13-18(19)24)21(14)15-5-8-17(25)9-6-15/h5-10,13H,2-4,11-12H2,1H3,(H,27,30)
InChI key
BUZAJRPLUGXRAB-UHFFFAOYSA-N
基因信息
mouse ... Cnr1(12801), Cnr2(12802)
rat ... Cnr1(25248)
相关类别
应用
AM251，一种CB1 大麻素受体拮抗剂，已被用于一项研究，以确定其与海马神经元的相互作用，以增强小鼠的空间记忆。
生化/生理作用
AM251是一种CB1 大麻素受体拮抗剂。
特点和优势
该化合物由Sanofi Aventis开发。要浏览其他药物开发化合物和批准的药物/候选药物列表，单击此处。
其他说明
盐含量可能会有所不同。
危险声明
预防措施声明
危险分类
Aquatic Chronic 4
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Nozomi Asaoka et al.
The Journal of toxicological sciences, 41(6), 813-816 (2016-11-18)
N-[[1-(5-fluoropentyl)-1H-indazol-3-yl]carbonyl]-3-methyl-D-valine methyl ester (5F-ADB) is one of the most potent synthetic cannabinoids and elicits severe psychotic symptoms in humans, sometimes causing death. To investigate the neuronal mechanisms underlying its toxicity, we examined the effects of 5F-ADB on midbrain dopaminergic and
Elahe Mohammadi Vosough et al.
Life sciences, 232, 116670-116670 (2019-07-23)
Migraine is a neurological debilitating disorder. Previous studies have shown that cannabinoid receptor agonists have analgesic effects in various models of pain. In this study, therefore, we investigated anti-nociceptive effects of WIN 55,212-2, and the role of either CB1 or
Ramy Khella et al.
Psychopharmacology, 231(16), 3071-3087 (2014-04-08)
Whilst cannabinoid CB2 receptors were thought to exist predominantly in immune cells in the periphery, the recent discovery of CB2 receptors in the brain has led to an increased interest in the role of these central CB2 receptors. Several studies
Danilo De Gregorio et al.
Pain, 160(1), 136-150 (2018-08-30)
Clinical studies indicate that cannabidiol (CBD), the primary nonaddictive component of cannabis that interacts with the serotonin (5-HT)1A receptor, may possess analgesic and anxiolytic effects. However, its effects on 5-HT neuronal activity, as well as its impact on models of
Mahsa Shahidi et al.
The Journal of general virology, 95(Pt 11), 2468-2479 (2014-07-24)
Direct-acting antivirals have significantly improved treatment outcomes in chronic hepatitis C (CHC), but side effects, drug resistance and cost mean that better treatments are still needed. Lipid metabolism is closely linked with hepatitis C virus (HCV) replication, and endocannabinoids are
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