A6433
Acetyl-Ser-Asp-Lys-Pro
≥97% (HPLC)
别名:
AcSDKP, Acetyl-SDKP
登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式（希尔记法）:
C20H33N5O9
化学文摘社编号:
分子量:
487.50
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
产品名称
Acetyl-Ser-Asp-Lys-Pro, ≥97% (HPLC)
InChI
1S/C20H33N5O9/c1-11(27)22-14(10-26)18(31)24-13(9-16(28)29)17(30)23-12(5-2-3-7-21)19(32)25-8-4-6-15(25)20(33)34/h12-15,26H,2-10,21H2,1H3,(H,22,27)(H,23,30)(H,24,31)(H,28,29)(H,33,34)
SMILES string
CC(=O)NC(CO)C(=O)NC(CC(O)=O)C(=O)NC(CCCCN)C(=O)N1CCCC1C(O)=O
InChI key
HJDRXEQUFWLOGJ-UHFFFAOYSA-N
assay
≥97% (HPLC)
form
powder
color
white
UniProt accession no.
storage temp.
−20°C
Gene Information
human ... GCG(2641)
Biochem/physiol Actions
Acetyl Ser-Asp-Lys-Pro is formed in bone marrow cells by enzymatic processing of thymosin β4. It inhibits the entry of pluripotent hemopoietic stem cells into S-phase of the cell cycle and protects against Ara-C lethality in mice. It is a specific substrate for the N-terminal active site of angiotensin converting enzyme, which is responsible for its degradation in vivo.
存储类别
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Kenneth E Bernstein et al.
Current opinion in pharmacology, 11(2), 105-111 (2010-12-07)
Angiotensin-converting enzyme (ACE) can cleave angiotensin I, bradykinin, neurotensin and many other peptide substrates in vitro. In part, this is due to the structure of ACE, a protein composed of two independent catalytic domains. Until very recently, little was known
Yuan-Wen Chen et al.
Journal of hepatology, 53(3), 528-536 (2010-07-22)
N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous tetrapeptide which has antifibrogenic effects at physiological concentrations in various tissues. AcSDKP is produced locally in the liver, however, little is known about its biological effect in this organ. We hypothesize that basal levels of
Nour-Eddine Rhaleb et al.
Journal of hypertension, 29(2), 330-338 (2010-11-06)
Hypertension-induced renal injury is characterized by inflammation, fibrosis and proteinuria. Previous studies have demonstrated that N-acetyl-Ser-Asp-Lys-Pro (Ac-SDKP) inhibits renal damage following diabetes mellitus and antiglomerular basement membrane nephritis. However, its effects on low-renin hypertensive nephropathy are not known. Thus, we
Hongmei Peng et al.
American journal of physiology. Heart and circulatory physiology, 298(5), H1357-H1364 (2010-02-16)
N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) inhibits collagen production and cell proliferation in cultured rat cardiac fibroblasts, but its effect on differentiation of fibroblasts into myofibroblasts is not known. High amounts of transforming growth factor-beta1 (TGF-beta1) have been found in fibrotic cardiac tissue. TGF-beta1
Jian-Miao Liu et al.
Annals of the New York Academy of Sciences, 1194, 53-59 (2010-06-12)
The natural tetrapeptide acetyl-ser-asp-lys-pro (AcSDKP) is formed in vivo by enzymatic cleavage of the N terminus of thymosin beta4 by prolyl oligopeptidase (POP). Recently, AcSDKP was shown to promote angiogenesis. Because of the critical role of neovascularization in cancer development
我们的科学家团队拥有各种研究领域经验，包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持