A6681
2-Acetamido-1-N-(β-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine
≥98%
别名:
β-D-GlcNAc-(1→N)-Asn, 2-Acetamido-1-β-(L-aspartamido)-1,2-dideoxy-D-glucose, L-Asparagine, N-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]
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关于此项目
经验公式（希尔记法）:
C12H21N3O8
化学文摘社编号:
分子量:
335.31
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
InChI
1S/C12H21N3O8/c1-4(17)14-8-10(20)9(19)6(3-16)23-11(8)15-7(18)2-5(13)12(21)22/h5-6,8-11,16,19-20H,2-3,13H2,1H3,(H,14,17)(H,15,18)(H,21,22)
SMILES string
CC(=O)NC1C(O)C(O)C(CO)OC1NC(=O)CC(N)C(O)=O
InChI key
YTTRPBWEMMPYSW-UHFFFAOYSA-N
assay
≥98%
form
powder
optical activity
[α]/D 22 to 26 °, c = 1% (w/v) in water
technique(s)
thin layer chromatography (TLC): suitable
storage temp.
−20°C
Application
n-acetylglucosaminylasparagine [2-Acetamido-1-N-(β-L-aspartyl)-2-deoxy-β-D-glucopyranosylamine] may be useful in studies on Aspartylglycosaminuria.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
A Schäfer et al.
Carbohydrate research, 313(2), 107-116 (1999-01-09)
The preparative synthesis of a new N4-(2-acetamido-2-deoxy-beta-D-glucopyranosyl)-L-asparagine mimetic 1, starting from 2-amino-1,5-anhydro-2-deoxy-glucitol hydrochloride and Z-Asp-(OH)-OBn is described. This glycosyl-amino acid unit 1 is expected to show higher stabilities towards in vivo conditions. Further, the use of 1 as building block
Ulla Dunder et al.
Journal of inherited metabolic disease, 33(5), 611-617 (2010-07-08)
Aspartylglycosaminuria (AGU) is a lysosomal storage disease caused by deficient activity of glycosylasparaginase (AGA), and characterized by motor and mental retardation. Enzyme replacement therapy (ERT) in adult AGU mice with AGA removes the accumulating substance aspartylglucosamine from and reverses pathology
E Vargas-Díez et al.
The British journal of dermatology, 147(4), 760-764 (2002-10-09)
Angiokeratoma corporis diffusum (ACD), initially considered to be synonymous with Fabry's disease, represents a well-known cutaneous marker of some other lysosomal enzyme disorders. Aspartylglucosaminuria (AGU) is a rare hereditary disorder mostly affecting the Finnish population, with only a few sporadic
T Autti et al.
Acta radiologica (Stockholm, Sweden : 1987), 49(6), 687-692 (2008-06-24)
Aspartylglucosaminuria (AGU) is an autosomal recessive lysosomal disease caused by deficiency of aspartylglucosaminidase. A thalamic T2 signal intensity decrease is associated with lysosomal diseases. To investigate thalamic signal intensity in AGU by performing a retrospective review of brain magnetic resonance
J M Risley et al.
Journal of enzyme inhibition, 16(3), 269-274 (2001-11-08)
Glycosylasparaginase catalyzes the hydrolysis of the N-glycosylic bond between asparagine and N-acetylglucosamine in the catabolism of N-linked glycoproteins. Previously only three competitive inhibitors, one noncompetitive inhibitor, and one irreversible inhibitor of glycosylasparaginase activity had been reported. Using human glycosylasparaginase from
商品
N-linked glycosylation, modification, and degradation
N-连接聚糖、修饰和降解
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