A6733
金诺芬
≥98% (HPLC), powder, leukocyte activation pathway inhibitor
别名:
1-硫醇-β-D-吡喃葡萄糖基三乙基膦金2,3,4,6-四乙酸酯, 3,4,5-三乙酰氧基-6-（乙酰氧基甲基）恶烷-2-硫醇盐三乙基磷, SKF 39162
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关于此项目
经验公式（希尔记法）:
C20H34AuO9PS
CAS Number:
分子量:
678.48
EC 号:
MDL编号:
UNSPSC代码:
51111800
PubChem化学物质编号:
NACRES:
NA.77
Product Name
金诺芬, ≥98% (HPLC)
质量水平
方案
≥98% (HPLC)
表单
powder
溶解性
DMSO: ≥5 mg/mL
创始人
Prometheus
储存温度
room temp
SMILES字符串
CCP(CC)(CC)=[Au]S[C@@H]1O[C@H](COC(C)=O)[C@@H](OC(C)=O)[C@H](OC(C)=O)[C@H]1OC(C)=O
InChI
1S/C14H20O9S.C6H15P.Au/c1-6(15)19-5-10-11(20-7(2)16)12(21-8(3)17)13(14(24)23-10)22-9(4)18;1-4-7(5-2)6-3;/h10-14,24H,5H2,1-4H3;4-6H2,1-3H3;/q;;+1/p-1/t10-,11-,12+,13-,14+;;/m1../s1
InChI key
AUJRCFUBUPVWSZ-XTZHGVARSA-M
应用
金诺芬可在多个位点抑制白细胞活化途径，还可抑制人巨噬细胞、嗜碱性粒细胞和肺肥大细胞释放炎症介质。 金诺芬还可修饰IKKβ亚基5的Cys-179和参与氧化应激防御的硒酶硫氧还蛋白还原酶（TrxR），从而抑制人嗜中性粒细胞5-脂氧合酶和IKB激酶（IKK）。 金诺芬是一种改善病情的抗风湿药（DMARD），可用于研究抗OVCAR-3人卵巢癌细胞增殖作用。
生化/生理作用
金诺芬可在多个位点抑制多条白细胞活化途径。金诺芬可抑制人巨噬细胞、嗜碱性粒细胞和肺肥大细胞释放炎症介质。该化合物还抑制人嗜中性粒细胞中的5-脂氧合酶。金诺芬是一种可改善病情的抗风湿药（DMARD）。该化合物是有效的硒酶硫氧还蛋白还原酶（TrxR）抑制剂，可参与防御氧化应激。金诺芬是钙离子存在下线粒体膜通透性转换孔的有效诱导剂，其作用机制与抑制线粒体硫氧还蛋白还原酶有关。金诺芬通过修饰IKKβ亚基5的Cys-179抑制IKB激酶（IKK）。
金诺芬可在多个位点抑制多条白细胞活化途径，是一种可改善病情的抗风湿药（DMARD）。。
特点和优势
该化合物由 Prometheus开发。想要浏览其他由制药公司开发的化合物以及已批准药物/候选药物清单， 请单击此处。
警示用语：
Danger
危险声明
危险分类
Acute Tox. 3 Oral - Repr. 2
储存分类代码
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Samuel Pearson et al.
Chemical communications (Cambridge, England), 48(39), 4695-4697 (2012-04-05)
Polymeric versions of deacetylated auranofin, a gold complex with a sugar ligand, were prepared by post-modifying RAFT glycopolymers. Micellisation of a block copolymer containing pendant Au(I) units produced nanoparticles with an increased anti-proliferative effect against OVCAR-3 human ovarian carcinoma cells.
Jong-Lyel Roh et al.
Antioxidants & redox signaling, 27(2), 106-114 (2016-10-14)
The glutathione (GSH), thioredoxin (Trx), and Nrf2 systems represent a major defense against reactive oxygen species (ROS), the cellular imbalance of which in cancer promotes growth and therapeutic resistance. This study investigated whether targeting the GSH, Trx, and Nrf2 antioxidant
Lorenzo Turcano et al.
PLoS neglected tropical diseases, 12(11), e0006969-e0006969 (2018-11-27)
Trypanothione reductase (TR) is considered to be one of the best targets to find new drugs against Leishmaniasis. This enzyme is fundamental for parasite survival in the host since it reduces trypanothione, a molecule used by the tryparedoxin/tryparedoxin peroxidase system
Julia Sajman et al.
Scientific reports, 7(1), 11350-11350 (2017-09-14)
The secretory signal elicited by membrane depolarization traverses from the Ca
Amir Ata Saei et al.
Redox biology, 32, 101491-101491 (2020-03-22)
Chemical proteomics encompasses novel drug target deconvolution methods in which compound modification is not required. Herein we use Thermal Proteome Profiling, Functional Identification of Target by Expression Proteomics and multiplexed redox proteomics for deconvolution of auranofin targets to aid elucidation
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