InChI key
YBFLMRSYEWDJEJ-ZNHDNBJUSA-N
InChI
1S/C18H26NO3.BrH/c1-19(2)14-8-9-15(19)11-16(10-14)22-18(21)17(12-20)13-6-4-3-5-7-13;/h3-7,14-17,20H,8-12H2,1-2H3;1H/t14-,15+,16?,17?;
SMILES string
Br.C[N]1(C)[C@@H]2CC[C@H]1C[C@@H](C2)OC(=O)C(CO)c3ccccc3
assay
≥99% (TLC)
form
powder
color
white to off-white
solubility
H2O: 50 mg/mL
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
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Biochem/physiol Actions
Competitive muscarinic acetylcholine receptor antagonist that does not cross the blood-brain barrier.
G J Kirouac et al.
The American journal of physiology, 273(6 Pt 2), H2549-H2557 (1998-01-22)
Experiments were done in alpha-chloralose-anesthetized, paralyzed, and artificially ventilated rats to investigate the effect of L-glutamate (Glu) stimulation of the substantia nigra (SN) and ventral tegmental area (VTA) on arterial pressure (AP) and heart rate (HR). Glu stimulation of the
Timothy A Yap et al.
Molecular cancer therapeutics, 10(2), 360-371 (2010-12-31)
AKT is frequently deregulated in cancer, making it an attractive anticancer drug target. CCT128930 is a novel ATP-competitive AKT inhibitor discovered using fragment- and structure-based approaches. It is a potent, advanced lead pyrrolopyrimidine compound exhibiting selectivity for AKT over PKA
M M Knuepfer et al.
The American journal of physiology, 276(1 Pt 2), R103-R112 (1999-01-14)
It has been suggested that toxicity to cocaine is related to the relative rate of cocaine metabolism by cholinesterases and to activation of cholinergic receptors either directly or by reflex mechanisms. We examined these possibilities by altering cholinesterase activity and
H Ohnuma et al.
Journal of the autonomic nervous system, 57(1-2), 43-48 (1996-02-05)
Hepatic glucoreceptor-vagal afferent inputs to the central nervous system and pancreatic vagal efferent stimuli are important for insulin secretion. In the present study, we examined the effect of intracerebroventricular (i.c.v.) injection of atropine methyl bromide (methylatropine) on the insulin response
Siew Kian Tai et al.
Hippocampus, 22(4), 914-925 (2011-05-05)
The vestibular system has been suggested to participate in spatial navigation, a function ascribed to the hippocampus. Vestibular stimulation during spatial navigation activates a hippocampal theta rhythm (4-10 Hz), which may enhance spatial processing and motor response. We hypothesize that
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