A7127
胍丁胺 硫酸盐
≥97% (TLC), powder, ion channel blocker
别名:
1-氨基-4-胍基丁烷 硫酸盐, 4-胍基丁胺 硫酸盐, N -（4-氨基丁基）胍 硫酸盐
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关于此项目
线性分子式:
H2N(CH2)4NHC(=NH)NH2·H2SO4
化学文摘社编号:
分子量:
228.27
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
219-617-3
MDL number:
Beilstein/REAXYS Number:
3918807
产品名称
胍丁胺 硫酸盐, ≥97%, powder
InChI
1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
SMILES string
OS(O)(=O)=O.NCCCCNC(N)=N
InChI key
PTAYFGHRDOMJGC-UHFFFAOYSA-N
assay
≥97%
form
powder
color
white to off-white
mp
234-238 °C (lit.)
solubility
H2O: 50 mg/mL
ethanol: insoluble
Quality Level
Gene Information
human ... ADRA2A(150), ADRA2B(151), ADRA2C(152), GRIN1(2902), GRIN2A(2903), GRIN2B(2904), GRIN2C(2905), GRIN2D(2906), GRINA(2907)
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相关类别
Application
胍丁胺硫酸盐已用于：
- 研究其对亚慢性束缚应激大鼠模型中NOD样受体蛋白 3 (NLRP3) 炎症小体活化和细胞因子响应的影响
- 用作N-甲基-D-天冬氨酸 (NMDA) 受体阻断剂，研究其对丙戊酸诱导的自闭症动物模型的自闭症行为的治疗作用
- 用作标准品，通过高效液相色谱法（HPLC）测定蔬菜中的生物活性胺
Biochem/physiol Actions
咪唑啉受体介导的内源性神经递质；在 α 取代可乐定 2 -肾上腺素能受体和咪唑啉受体；阻断海马神经元中 NMDA 激活的离子通道。
胍丁胺是一种脱羧精氨酸，在所有生物体中普遍存在。在动植物来源食品中，都可发现这一物质。它对多种身体机能表现出低温保护作用，例如肾保护、神经保护、胃保护和心脏保护。胍丁胺还对神经创伤、神经性疼痛、糖尿病、神经退行性疾病和精神疾病具有治疗作用。它参与阻断许多离子通道，例如ATP敏感的K+通道和电压门控Ca2+通道。胍丁胺可调节一氧化氮生产，并抑制基质金属蛋白酶。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Vegetables consumed in Brazilian cuisine as sources of bioactive amines
Dala P B M, et al.
Food Bioscience, 40, 100856-100856 (2021)
Ceren Sahin et al.
Basic & clinical pharmacology & toxicology, 119(4), 367-375 (2016-04-12)
The activation of Nod-like receptor protein 3 (NLRP3) has lately been implicated in stress and depression as an initiator mechanism required for the production of interleukin (IL)-1β and IL-18. Agmatine, an endogenous polyamine widely distributed in mammalian brain, is a
Ji-Woon Kim et al.
Neuropharmacology, 113(Pt A), 71-81 (2016-11-05)
Autism spectrum disorder (ASD) is an immensely challenging developmental disorder characterized primarily by two core behavioral symptoms of social communication deficits and restricted/repetitive behaviors. Investigating the etiological process and identifying an appropriate therapeutic target remain as formidable challenges to overcome
X C Yang et al.
The Journal of pharmacology and experimental therapeutics, 288(2), 544-549 (1999-01-26)
We investigated in rat hippocampus neurons whether 4-(aminobutyl)guanidine (agmatine), formed by decarboxylation of L-arginine by arginine decarboxylase and metabolized to urea and putrescine, can modulate the function of N-methyl-D-aspartate (NMDA) receptor channels. In cultured hippocampal neurons studied by whole-cell patch
Nicolò Mauro et al.
Scientific reports, 6, 33393-33393 (2016-09-20)
The initial steps of viral infections are mediated by interactions between viral proteins and cellular receptors. Blocking the latter with high-affinity ligands may inhibit infection. DC-SIGN, a C-type lectin receptor expressed by immature dendritic cells and macrophages, mediates human immunodeficiency
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