A7479
5-AIQ hydrochloride
≥97% (HPLC), solid
别名:
5-Aminoisoquinolinone hydrochloride
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关于此项目
经验公式（希尔记法）:
C9H9ClN2O
化学文摘社编号:
分子量:
196.63
MDL编号:
UNSPSC代码:
12352202
PubChem化学物质编号:
NACRES:
NA.77
方案
≥97% (HPLC)
表单
solid
颜色
tan
溶解性
DMSO: >20 mg/mL
H2O: >20 mg/mL
储存温度
−20°C
SMILES字符串
Cl[H].Nc1cccc2C(=O)NC=Cc12
InChI
1S/C9H8N2O.ClH/c10-8-3-1-2-7-6(8)4-5-11-9(7)12;/h1-5H,10H2,(H,11,12);1H
InChI key
KWNLARCFSYAXLT-UHFFFAOYSA-N
相关类别
应用
5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1). 5-AIQ hydrochloride was used in a study that determined PARP inhibitors have antiangiogenic effects, which may have tremendous clinical implications for the treatment of various cancers and certain retinopathies.
生化/生理作用
5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1).
警示用语：
Warning
危险声明
危险分类
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
靶器官
Respiratory system
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Mohanraj Rajesh et al.
Biochemical and biophysical research communications, 350(4), 1056-1062 (2006-10-19)
Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation. We
Adrian C Nicolescu et al.
Biochemical and biophysical research communications, 387(4), 646-650 (2009-07-22)
Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidative stress associated with various pathologies. As MMP-2 plays a detrimental role in heart injuries resulting from enhanced nitroxidative
Yi Yuan et al.
Journal of tissue engineering and regenerative medicine, 13(9), 1499-1506 (2019-02-28)
Adipose tissues regenerated using tissue engineering chambers (TECs) show the potential for applications in reconstruction of soft tissue defects. Previous studies have shown that early inflammation plays a key role in angiogenesis and adipogenesis required for adipose tissue generation. However
Ming Li et al.
Pathobiology : journal of immunopathology, molecular and cellular biology, 76(3), 108-116 (2009-05-27)
The current study was designed to test the hypothesis that inhibition of poly(ADP-ribose) polymerase in colorectal cancer mediates down-regulation of metastasis-related gene expression through the regulation of nuclear factor-kappaB (NF-kappaB) activity. Mouse colon carcinoma cells (CT26) were treated with and
Arnaud J Legrand et al.
PloS one, 8(2), e55883-e55883 (2013-02-14)
Ets-1 is a transcription factor that regulates many genes involved in cancer progression and in tumour invasion. It is a poor prognostic marker for breast, lung, colorectal and ovary carcinomas. Here, we identified poly(ADP-ribose) polymerase-1 (PARP-1) as a novel interaction
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