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A7479

5-AIQ hydrochloride

≥97% (HPLC), solid

别名:

5-Aminoisoquinolinone hydrochloride

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关于此项目

经验公式（希尔记法）:
C9H9ClN2O
化学文摘社编号:
93117-07-8
分子量:
196.63
NACRES:
NA.77
PubChem Substance ID:
24724396
UNSPSC Code:
12352202
MDL number:
MFCD03452659
Assay:
≥97% (HPLC)
Form:
solid
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assay

≥97% (HPLC)

form

solid

color

tan

solubility

DMSO: >20 mg/mL, H2O: >20 mg/mL

storage temp.

−20°C

SMILES string

Cl[H].Nc1cccc2C(=O)NC=Cc12

InChI

1S/C9H8N2O.ClH/c10-8-3-1-2-7-6(8)4-5-11-9(7)12;/h1-5H,10H2,(H,11,12);1H

InChI key

KWNLARCFSYAXLT-UHFFFAOYSA-N

Application

5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1). 5-AIQ hydrochloride was used in a study that determined PARP inhibitors have antiangiogenic effects, which may have tremendous clinical implications for the treatment of various cancers and certain retinopathies.

Biochem/physiol Actions

5-AIQ hydrochloride is an inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1).

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number
128K4615
124K4610

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Mohanraj Rajesh et al.
Biochemical and biophysical research communications, 350(4), 1056-1062 (2006-10-19)
Inhibitors of poly(ADP-ribose)polymerase (PARP), a nuclear enzyme involved in regulating cell death and cellular responses to DNA repair, show considerable promise in the treatment of cancer both in monotherapy as well as in combination with chemotherapeutic agents and radiation. We
Yi Yuan et al.
Journal of tissue engineering and regenerative medicine, 13(9), 1499-1506 (2019-02-28)
Adipose tissues regenerated using tissue engineering chambers (TECs) show the potential for applications in reconstruction of soft tissue defects. Previous studies have shown that early inflammation plays a key role in angiogenesis and adipogenesis required for adipose tissue generation. However
Adrian C Nicolescu et al.
Biochemical and biophysical research communications, 387(4), 646-650 (2009-07-22)
Matrix metalloproteinase-2 (MMP-2), a ubiquitously expressed zinc-dependent endopeptidase, and poly(ADP-ribosyl) polymerase (PARP), a nuclear enzyme regulating DNA repair, are activated by nitroxidative stress associated with various pathologies. As MMP-2 plays a detrimental role in heart injuries resulting from enhanced nitroxidative
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全球贸易项目编号

货号GTIN
A7479-5MG04061833267585
A7479-1MG04061826671054