A8054
D(-)-2-氨基-5-膦戊酸
NMDA receptor antagonist
别名:
D -2-氨基-5-膦酰戊酸, D(-)-AP-5, D(-)-APV
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选择尺寸
关于此项目
经验公式（希尔记法）:
C5H12NO5P
化学文摘社编号:
分子量:
197.13
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
产品名称
D(-)-2-氨基-5-膦戊酸, NMDA receptor antagonist
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
SMILES string
N[C@H](CCCP(O)(O)=O)C(O)=O
InChI key
VOROEQBFPPIACJ-SCSAIBSYSA-N
assay
≥98% (TLC)
form
powder
optical purity
optical purity: ≥90% (HPLC, Marfey′s reagent)
technique(s)
ligand binding assay: suitable
color
white
mp
245-246 °C
Quality Level
Gene Information
mouse ... Grin2a(14811)
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410), Grin2c(24411), Grin2d(24412)
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Application
D (-)-2-氨基-5-膦戊酸已被用于预处理 BNST（终纹床核），以阻止 ORX-A（食欲素-A）引入 BNST 的焦虑。
Biochem/physiol Actions
NMDA 拮抗剂具有肌肉松弛属性，对缺血引起的脑损伤具有神经元保护作用。2-氨基-5-膦甲酸已被证明可以阻断离子导入引起的 NMDA 的去极化。
抗惊厥药；强效和选择性N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂；2-氨基-5-膦酰戊酸的活性对映体。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger gene expression and protein synthesis, leading to consolidation of synaptic and neuronal changes. However, while LTP and LTD have been proposed to play important roles for
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