A8054
D(-)-2-氨基-5-膦戊酸
NMDA receptor antagonist
别名:
D -2-氨基-5-膦酰戊酸, D(-)-AP-5, D(-)-APV
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关于此项目
经验公式（希尔记法）:
C5H12NO5P
化学文摘社编号:
分子量:
197.13
MDL编号:
UNSPSC代码:
12352106
PubChem化学物质编号:
NACRES:
NA.26
质量水平
方案
≥98% (TLC)
表单
powder
光学纯度
optical purity: ≥90% (HPLC, Marfey′s reagent)
技术
ligand binding assay: suitable
颜色
white
mp
245-246 °C
SMILES字符串
N[C@H](CCCP(O)(O)=O)C(O)=O
InChI
1S/C5H12NO5P/c6-4(5(7)8)2-1-3-12(9,10)11/h4H,1-3,6H2,(H,7,8)(H2,9,10,11)/t4-/m1/s1
InChI key
VOROEQBFPPIACJ-SCSAIBSYSA-N
基因信息
mouse ... Grin2a(14811)
rat ... Grik1(29559), Grin2a(24409), Grin2b(24410), Grin2c(24411), Grin2d(24412)
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应用
D (-)-2-氨基-5-膦戊酸已被用于预处理 BNST（终纹床核），以阻止 ORX-A（食欲素-A）引入 BNST 的焦虑。
生化/生理作用
NMDA 拮抗剂具有肌肉松弛属性，对缺血引起的脑损伤具有神经元保护作用。2-氨基-5-膦甲酸已被证明可以阻断离子导入引起的 NMDA 的去极化。
抗惊厥药；强效和选择性N-甲基-D-天冬氨酸 (NMDA) 受体拮抗剂；2-氨基-5-膦酰戊酸的活性对映体。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
dust mask type N95 (US), Eyeshields, Gloves
Synaptic Plasticity and Learning: Selective Impairment of Learning in
Rats and Blockade of Long-Term Potentiation in viva by the
IV-Methyl-D-Aspartate Receptor Antagonist AP5
Rats and Blockade of Long-Term Potentiation in viva by the
IV-Methyl-D-Aspartate Receptor Antagonist AP5
R. G. M. Morris
The Journal of Neuroscience, 9(9), 3040-3057 (1989)
Paola Conti et al.
European journal of medicinal chemistry, 42(8), 1059-1068 (2007-03-10)
Twelve novel conformationally constrained homologues of glutamic acid have been synthesized and pharmacologically characterized at ionotropic glutamate receptors (iGluRs). Synthesis of the target compounds involved 1,3-dipolar cycloaddition of nitrile oxides to suitable dipolarophiles. The structure to the compounds has been
Orexin-A Induces Anxiety-like Behavior through Interactions with Glutamatergic Receptors in the Bed Nucleus of the Stria Terminalis of Rats
Elizabeth A Lungwitz
Physiology & Behavior, 107(5), 726-732 (2012)
Daniela Gandolfi et al.
Frontiers in cellular neuroscience, 11, 184-184 (2017-07-14)
The induction of long-term potentiation and depression (LTP and LTD) is thought to trigger gene expression and protein synthesis, leading to consolidation of synaptic and neuronal changes. However, while LTP and LTD have been proposed to play important roles for
Excitatory amino acid transmitters.
J C Watkins et al.
Annual review of pharmacology and toxicology, 21, 165-204 (1981-01-01)
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