A8111
Plasminogen activator inhibitor 1 (PAI-1)
≥200,000 units/mg protein, lyophilized powder, ≥90% (SDS-PAGE)
别名:
PAIE, PLANH1, Serpin E1 PAI-1, Serpine 1, 血纤维蛋白溶酶原激活物抑制剂，β-迁移内皮细胞衍生型
Product Name
血纤维蛋白溶酶原激活物抑制剂1(PAI-1) 人, recombinant, expressed in E. coli, ≥90% (SDS-PAGE)
重组
expressed in E. coli
质量水平
方案
≥90% (SDS-PAGE)
表单
lyophilized powder
比活
≥200,000 units/mg protein
分子量
~43 kDa
溶解性
water: 0.1 mL, clear, colorless
UniProt登记号
运输
dry ice
储存温度
−20°C
基因信息
human ... SERPINE1(5054)
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一般描述
纤溶酶原激活物抑制剂1 (PAI-1)或丝氨酸蛋白酶抑制剂E1 (SERPINE1)基因映射到人类染色体7q22.1。PAI-1在肝细胞、内皮细胞、平滑肌细胞、巨核细胞和脂肪细胞中产生。
应用
人纤溶酶原激活物抑制剂1 (PAI-1)已被用作：
- 放射免疫沉淀法(RIPA)中的脑源性神经营养因子(proBDNF)的抑制剂，用于外周血和淋巴细胞
- 阻断感染白色念珠菌菌丝
- 小鼠的纤溶酶活性，检测其对神经元神经突生长的影响
生化/生理作用
纤溶酶原激活物抑制剂1 (PAI -1)参与介导细胞衰老。它在损伤期间与其他组织修复转录组一起上调。PAI-1水平升高被认为是与心肌梗死(MI)相关的风险之一。
纤溶酶原激活物抑制剂1（PAI-1）是丝氨酸蛋白酶抑制剂Serpin超家族的一员，可参与到细胞外基质重塑并涉及血管生成、趋化性、排卵和胚胎生成等过程。
纤溶酶原激活物抑制剂1（PAI-1）蛋白属于丝氨酸蛋白酶抑制剂的Serpin超家族。它是组织纤溶酶原激活物（tPA）和尿激酶（uPA）的主要抑制剂，并也是纤溶酶原的激活剂，因此可抑制纤维蛋白溶解过程。 PAI可参与到细胞外基质的重塑，并涉及血管生成、趋化性、排卵和胚胎生成等过程。 PAI-1在各种疾病状态中的水平都有所上升，如多种癌症形式、肥胖症和代谢综合征。
外形
以含有0.5 M氯化钠、20 mM 乙酸钠和50 mg/mL 海藻糖的一种溶液冻干粉形式提供。
制备说明
用超纯水重悬成0.25 mg/ml。在0.5 M氯化钠、20 mM 乙酸钠和50 mg/mL 海藻糖中，含重悬产物0.25 mgP/mL。
分析说明
该产品是一种活性人PAI-1蛋白，分子量为43 kDa。
其他说明
1单位可在生理状态下（中性pH和37 ºC）不可逆的抑制（100%抑制）1单位的组织纤溶酶原激活物（tPA）。
储存分类代码
10 - Combustible liquids
WGK
WGK 1
闪点(°F)
Not applicable
闪点(°C)
Not applicable
法规信息
常规特殊物品
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
Kirwin M Providence et al.
Archives of dermatological research, 300(6), 303-310 (2008-04-04)
Cutaneous tissue injury, both in vivo and in vitro, initiates activation of a "wound repair" transcriptional program. One such highly induced gene encodes plasminogen activator inhibitor type-1 (PAI-1, SERPINE1). PAI-1-GFP, expressed as a fusion protein under inducible control of +800
Liying Lin et al.
Journal of psychiatric research, 133, 166-173 (2020-12-21)
Previous studies showed that blood BDNF levels in mood disorders were reduced. However, little is known about the changes of BDNF and its precursor proBDNF in lymphocytes. In addition, earlier studies using commercial ELISA kits cannot distinguish mature BDNF from
William Santus et al.
Science immunology, 2(15) (2017-09-25)
Nuclear factor of activated T cells (NFAT) is activated in innate immune cells downstream of pattern recognition receptors, but little is known about NFAT's functions in innate immunity compared with adaptive immunity. We show that early activation of NFAT balances
Sadiya S Khan et al.
Science advances, 3(11), eaao1617-eaao1617 (2017-11-21)
Plasminogen activator inhibitor-1 (PAI-1) has been shown to be a key component of the senescence-related secretome and a direct mediator of cellular senescence. In murine models of accelerated aging, genetic deficiency and targeted inhibition of PAI-1 protect against aging-like pathology
Laura Yunes-Medina et al.
Molecular and cellular neurosciences, 86, 72-80 (2017-12-05)
The protein transglutaminase 2 (TG2) has been implicated as a modulator of neuronal viability. TG2's role in mediating cell survival processes has been suggested to involve its ability to alter transcriptional events. The goal of this study was to examine
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