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A8398

7-氨基去乙酰氧基头孢烷酸

Name: 7-氨基去乙酰氧基头孢烷酸
Brand: SIGMA

别名:

7-ADCA

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关于此项目

经验公式（希尔记法）:

C₈H₁₀N₂O₃S

化学文摘社编号:

22252-43-3

分子量:

214.24

NACRES:

NA.85

PubChem Substance ID:

24891339

UNSPSC Code:

51102829

EC Number:

244-870-1

MDL number:

MFCD09750368

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form

powder or crystals

Quality Level

200

antibiotic activity spectrum

Gram-positive bacteria

mode of action

cell wall synthesis | interferes

storage temp.

2-8°C

SMILES string

CC1=C(N2[C@H](SC1)[C@H](N)C2=O)C(O)=O

InChI

1S/C8H10N2O3S/c1-3-2-14-7-4(9)6(11)10(7)5(3)8(12)13/h4,7H,2,9H2,1H3,(H,12,13)/t4-,7-/m1/s1

InChI key

NVIAYEIXYQCDAN-CLZZGJSISA-N

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General description

化学结构:β-内酰胺

Application

7-氨基去乙酰氧基头孢烷酸用于头孢菌素的合成和生物转化研究。

Biochem/physiol Actions

7-ADCA是由产黄青霉菌产生的青霉素G生产的，涉及几个污染的化学步骤，然后使用青霉素酰化酶进行酶脱酰。

Other Notes

保存于密闭容器内，置于干燥通风处。

hcodes

H412

pcodes

P273 - P501

Hazard Classifications

Aquatic Chronic 3

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Altering the substrate specificity of cephalosporin acylase by directed evolution of the Beta -subunit.

Linda G Otten et al.

The Journal of biological chemistry, 277(44), 42121-42127 (2002-08-29)

Using directed evolution, we have selected an adipyl acylase enzyme that can be used for a one-step bioconversion of adipyl-7-aminodesacetoxycephalosporanic acid (adipyl-7-ADCA) to 7-ADCA, an important compound for the synthesis of semisynthetic cephalosporins. The starting point for the directed evolution

Advantages of using non-isothermal bioreactors for the enzymatic synthesis of antibiotics: the penicillin G acylase as enzyme model.

P Travascio et al.

Biotechnology and bioengineering, 79(3), 334-346 (2002-07-13)

A new hydrophobic and catalytic membrane was prepared by immobilizing Penicillin G acylase (PGA, EC.3.5.1.11) from E. coli on a nylon membrane, chemically grafted with butylmethacrylate (BMA). Hexamethylenediamine (HMDA) and glutaraldehyde (Glu) were used as a spacer and coupling agent

Modeling of the enzymatic kinetic synthesis of cephalexin--influence of substrate concentration and temperature.

C G Schroën et al.

Biotechnology and bioengineering, 73(3), 171-178 (2001-03-21)

During enzymatic kinetic synthesis of cephalexin, an activated phenylglycine derivative (phenylglycine amide or phenylglycine methyl ester) is coupled to the nucleus 7-aminodeacetoxycephalosporanic acid (7-ADCA). Simultaneously, hydrolysis of phenylglycine amide and hydrolysis of cephalexin take place. This results in a temporary

Continuous cultivations of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus: Growth yields and morphological characterization.

J Robin et al.

Biotechnology and bioengineering, 83(3), 361-368 (2003-06-05)

The growth stoichiometry of a Penicillium chrysogenum strain expressing the expandase gene from Streptomyces clavuligerus was determined in glucose-limited chemostat cultivations using a chemically defined medium. This strain produces adipoyl-7-aminodeacetoxycephalosporanic acid (ad-7-ADCA) when it is fed with adipic acid. The

Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.

Linda G. Otten, Charles F. Sio, et al.

Chembiochem, 6, 820-825 (2004)

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全球贸易项目编号

货号	GTIN
A8398-5G	04061833391549
A8398-1G	04061833391525
A8398-250MG	04061833391532

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