A8398
7-氨基去乙酰氧基头孢烷酸
别名:
7-ADCA
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关于此项目
经验公式（希尔记法）:
C8H10N2O3S
化学文摘社编号:
分子量:
214.24
NACRES:
NA.85
PubChem Substance ID:
UNSPSC Code:
51102829
EC Number:
244-870-1
MDL number:
InChI key
NVIAYEIXYQCDAN-CLZZGJSISA-N
InChI
1S/C8H10N2O3S/c1-3-2-14-7-4(9)6(11)10(7)5(3)8(12)13/h4,7H,2,9H2,1H3,(H,12,13)/t4-,7-/m1/s1
SMILES string
CC1=C(N2[C@H](SC1)[C@H](N)C2=O)C(O)=O
form
powder or crystals
antibiotic activity spectrum
Gram-positive bacteria
mode of action
cell wall synthesis | interferes
storage temp.
2-8°C
Quality Level
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General description
化学结构:β-内酰胺
Application
7-氨基去乙酰氧基头孢烷酸用于头孢菌素的合成和生物转化研究。
Biochem/physiol Actions
7-ADCA是由产黄青霉菌产生的青霉素G生产的，涉及几个污染的化学步骤，然后使用青霉素酰化酶进行酶脱酰。
Packaging
无底玻璃瓶。内含物装在插入的融合锥内。
Other Notes
保存于密闭容器内，置于干燥通风处。
hcodes
pcodes
Hazard Classifications
Aquatic Chronic 3
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
Linda G Otten et al.
The Journal of biological chemistry, 277(44), 42121-42127 (2002-08-29)
Using directed evolution, we have selected an adipyl acylase enzyme that can be used for a one-step bioconversion of adipyl-7-aminodesacetoxycephalosporanic acid (adipyl-7-ADCA) to 7-ADCA, an important compound for the synthesis of semisynthetic cephalosporins. The starting point for the directed evolution
Mutational analysis of a key residue in the substrate specificity of a cephalosporin acylase.
Linda G. Otten, Charles F. Sio, et al.
Chembiochem, 6, 820-825 (2004)
R Saravanane et al.
Environmental technology, 30(10), 1016-1022 (2009-11-06)
The viability of treating high-concentration antibiotic wastewater by an anaerobic membrane bioreactor was studied using submerged flat sheet membrane. The objective of the study was to determine the effect of organic loading rate and hydraulic retention time on the removal
Wynand B L Alkema et al.
European journal of biochemistry, 270(18), 3675-3683 (2003-09-03)
Penicillin acylase catalyses the hydrolysis and synthesis of semisynthetic beta-lactam antibiotics via formation of a covalent acyl-enzyme intermediate. The kinetic and mechanistic aspects of these reactions were studied. Stopped-flow experiments with the penicillin and ampicillin analogues 2-nitro-5-phenylacetoxy-benzoic acid (NIPAOB) and
C G Schroën et al.
Biotechnology and bioengineering, 70(6), 654-661 (2000-11-07)
One of the building blocks of cephalosporin antibiotics is 7-amino-deacetoxycephalosporanic acid (7-ADCA). It is currently produced from penicillin G using an elaborate chemical ring-expansion step followed by an enzyme-catalyzed hydrolysis. However, 7-ADCA-like components can also be produced by direct fermentation.
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