A8727
安塔拉明 盐酸盐
≥98% (HPLC), solid, CRF1 antagonist
别名:
N-丁基-N-乙基-2,5,6-三甲基-7-（2,4,6-三甲基苯基）-7H-吡咯并[2,3-d]嘧啶-4-胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C24H34N4·HCl
化学文摘社编号:
分子量:
415.01
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
产品名称
安塔拉明 盐酸盐, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
off-white
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
InChI
1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChI key
CGDGXEDXEXACKQ-UHFFFAOYSA-N
相关类别
应用
Antalarmin 盐酸盐是一种非肽 CRF1 促肾上腺皮质激素释放因子受体拮抗剂。
Antalarmin盐酸盐的应用示例：
- 研究其对压力诱导的色氨酸羟化酶2活性的影响
- 研究促肾上腺皮质激素释放因子(CRF1)活化介导的焦虑作用
- 分析其阻断促肾上腺皮质激素(CRH)信号传导对社会压力诱导的抑郁的治疗作用
生化/生理作用
Antalarmin 盐酸盐是一种非肽 CRF1 促肾上腺皮质激素释放因子受体拮抗剂。
Antalarmin是非类固醇的怀孕抑制剂，即使在妊娠早期也能起到抑制效用。目前已确定它可延迟分娩。它还可抑制压力诱导的胃溃疡发展。
特点和优势
在《受体分类和信号转导》手册的 促肾上腺皮质激素释放因子受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
Rapid stress-induced transcriptomic changes in the brain depend on beta-adrenergic signaling
Roszkowski M, et al.
Neuropharmacology, 107, 329-338 (2016)
Pediatric Neuroendocrinology, 41-41 (2010)
Cecile Ducottet et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(4), 625-631 (2003-06-06)
Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression. Consequently, CRF receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects
Anna Skórzewska et al.
Stress (Amsterdam, Netherlands), 22(1), 113-122 (2018-10-23)
This study aimed to test the hypothesis that high-anxiety (HR) rats are more sensitive to the effects of chronic corticosterone administration and antalarmin (corticotropin-releasing factor (CRF) receptor 1, CRF1 antagonist) injections than low-anxiety (LR) rats, and this effect is accompanied
Nancy K Mello et al.
Pharmacology, biochemistry, and behavior, 85(4), 744-751 (2006-12-22)
Cocaine stimulates the rapid release of ACTH, and by inference, CRF in several species, suggesting that the HPA "stress" axis may contribute to the abuse-related effects of cocaine. The effects of a systemically-active CRF(1) receptor antagonist, antalarmin, on cocaine self-administration
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