A8727
安塔拉明 盐酸盐
≥98% (HPLC), solid, CRF1 antagonist
别名:
N-丁基-N-乙基-2,5,6-三甲基-7-（2,4,6-三甲基苯基）-7H-吡咯并[2,3-d]嘧啶-4-胺 盐酸盐
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关于此项目
经验公式（希尔记法）:
C24H34N4·HCl
CAS Number:
分子量:
415.01
MDL编号:
UNSPSC代码:
12352200
PubChem化学物质编号:
NACRES:
NA.77
Product Name
安塔拉明 盐酸盐, ≥98% (HPLC), solid
质量水平
方案
≥98% (HPLC)
表单
solid
储存条件
desiccated
颜色
off-white
溶解性
DMSO: >10 mg/mL
储存温度
2-8°C
SMILES字符串
Cl[H].CCCCN(CC)c1nc(C)nc2n(c(C)c(C)c12)-c3c(C)cc(C)cc3C
InChI
1S/C24H34N4.ClH/c1-9-11-12-27(10-2)23-21-18(6)19(7)28(24(21)26-20(8)25-23)22-16(4)13-15(3)14-17(22)5;/h13-14H,9-12H2,1-8H3;1H
InChI key
CGDGXEDXEXACKQ-UHFFFAOYSA-N
相关类别
应用
Antalarmin 盐酸盐是一种非肽 CRF1 促肾上腺皮质激素释放因子受体拮抗剂。
Antalarmin盐酸盐的应用示例：
- 研究其对压力诱导的色氨酸羟化酶2活性的影响
- 研究促肾上腺皮质激素释放因子(CRF1)活化介导的焦虑作用
- 分析其阻断促肾上腺皮质激素(CRH)信号传导对社会压力诱导的抑郁的治疗作用
生化/生理作用
Antalarmin 盐酸盐是一种非肽 CRF1 促肾上腺皮质激素释放因子受体拮抗剂。
Antalarmin是非类固醇的怀孕抑制剂，即使在妊娠早期也能起到抑制效用。目前已确定它可延迟分娩。它还可抑制压力诱导的胃溃疡发展。
特点和优势
在《受体分类和信号转导》手册的 促肾上腺皮质激素释放因子受体页有该化合物的介绍。想要浏览手册的其他页面， 请单击此处。
储存分类代码
11 - Combustible Solids
WGK
WGK 3
闪点(°F)
Not applicable
闪点(°C)
Not applicable
个人防护装备
Eyeshields, Gloves, type N95 (US)
历史批次信息供参考:
分析证书(COA)
Lot/Batch Number
CRF type 1 receptors of the medial amygdala modulate inhibitory avoidance responses in the elevated T-maze
Vicentini JE, et al.
Hormones and Behavior, 65(3), 195-202 (2014)
Deficits in KCC2 and activation of the HPA axis lead to depression-like behavior following social defeat
Miller S and Maguire J
Hormonal Studies, 2(1), 2-2 (2014)
Nancy K Mello et al.
Pharmacology, biochemistry, and behavior, 85(4), 744-751 (2006-12-22)
Cocaine stimulates the rapid release of ACTH, and by inference, CRF in several species, suggesting that the HPA "stress" axis may contribute to the abuse-related effects of cocaine. The effects of a systemically-active CRF(1) receptor antagonist, antalarmin, on cocaine self-administration
Cecile Ducottet et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(4), 625-631 (2003-06-06)
Several recent studies on corticotropin-releasing factor (CRF) have suggested that this neuropeptide may play a role in depression. Consequently, CRF receptor antagonists have been proposed as potential new agents for the treatment of this condition. This study investigated the effects
Pediatric Neuroendocrinology, 41-41 (2010)
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