A8852
A-68930 hydrochloride
≥98% (HPLC), powder
别名:
cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H17NO3 · HCl
化学文摘社编号:
分子量:
307.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
off-white to tan
solubility
H2O: soluble ~9 mg/mL
originator
Abbott
storage temp.
−20°C
SMILES string
Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)c3ccccc3
InChI
1S/C16H17NO3.ClH/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10;/h1-7,14-15,18-19H,8-9,17H2;1H/t14-,15-;/m0./s1
InChI key
PQPGUUQPTSMLKU-YYLIZZNMSA-N
Application
A-68930 hydrochloride has been used as a D1 receptor agonist to study its effect on striatal phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr15 in mice. It has also been used to study its effect on the cAMP accumulation in C-terminal mutant D1Rs in transfected HEK 293 cells.
Biochem/physiol Actions
A-68930 hydrochloride is a cell-membrane impermeable selective D1 dopamine receptor agonist.
A-68930 hydrochloride might possess antipsychotic properties.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H.A. AI-Naser et al.
Behavioural pharmacology, 5(2), 210-218 (1994-04-01)
A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK & F 38393, reduced food consumption in rats and mice. The aim of this study
P Salmi et al.
Neuroreport, 11(6), 1269-1272 (2000-05-19)
The present results demonstrate sedative effects of the DA D1 receptor agonist A 68930 (0.9-15 micromol kg(-1), s.c.) on rat spontaneous locomotor activity in an open field. The effects were particularly strong, and dose-dependent, for the ambulatory activity in the
J W Kebabian et al.
American journal of hypertension, 3(6 Pt 2), 40S-42S (1990-06-01)
A68930 (5,6-dihydroxy-3-phenyl-1-aminomethyl-isochroman) is a potent (EC50 = 2.5 nmol/L) partial agonist at the D-1 dopamine receptor. In contrast, A68930 is a much weaker agonist (EC50 = 3,920 nmol/L) at the D-2 dopamine receptor. The orientation of the 3-phenyl substituent in
Yan Guo et al.
PloS one, 6(12), e29204-e29204 (2011-12-30)
The dopamine D₁ receptor (D₁R), a G protein-coupled receptor, plays a critical role in regulating blood pressure through its actions on renal hemodynamics and epithelial ion transport, which are highly linked to its intracellular trafficking. In this study, we generated
Yukio Yamamura et al.
Frontiers in cellular neuroscience, 7, 12-12 (2013-02-20)
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in the striatum. c-Abelson
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