A8852
A-68930 hydrochloride
≥98% (HPLC), powder
别名:
cis-(±)-1-(Aminomethyl)-3,4-dihydro-3-phenyl-1H-2-benzopyran-5,6-diol hydrochloride
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关于此项目
经验公式（希尔记法）:
C16H17NO3 · HCl
化学文摘社编号:
分子量:
307.77
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI
1S/C16H17NO3.ClH/c17-9-15-11-6-7-13(18)16(19)12(11)8-14(20-15)10-4-2-1-3-5-10;/h1-7,14-15,18-19H,8-9,17H2;1H/t14-,15-;/m0./s1
SMILES string
Cl.NC[C@@H]1O[C@@H](Cc2c(O)c(O)ccc12)c3ccccc3
InChI key
PQPGUUQPTSMLKU-YYLIZZNMSA-N
assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
off-white to tan
solubility
H2O: soluble ~9 mg/mL
originator
Abbott
storage temp.
−20°C
Application
A-68930 hydrochloride has been used as a D1 receptor agonist to study its effect on striatal phosphorylation of cyclin-dependent kinase 5 (Cdk5) at Tyr15 in mice. It has also been used to study its effect on the cAMP accumulation in C-terminal mutant D1Rs in transfected HEK 293 cells.
Biochem/physiol Actions
A-68930 hydrochloride is a cell-membrane impermeable selective D1 dopamine receptor agonist.
A-68930 hydrochloride might possess antipsychotic properties.
Features and Benefits
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
H.A. AI-Naser et al.
Behavioural pharmacology, 5(2), 210-218 (1994-04-01)
A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, SK & F 38393, reduced food consumption in rats and mice. The aim of this study
P Salmi et al.
Neuroreport, 11(6), 1269-1272 (2000-05-19)
The present results demonstrate sedative effects of the DA D1 receptor agonist A 68930 (0.9-15 micromol kg(-1), s.c.) on rat spontaneous locomotor activity in an open field. The effects were particularly strong, and dose-dependent, for the ambulatory activity in the
R Isacson et al.
Neuroscience, 124(1), 33-42 (2004-02-13)
The behavioral and biochemical effects of the full dopamine D(1/5) receptor agonists, dihydrexidine and (1R,3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCl (A 68930), were examined in rats. Both A 68930 (0-4.6 mg kg(-1), s.c.) and dihydrexidine (0-8.0 mg kg(-1), s.c.) caused a dose-dependent suppression of
Yukio Yamamura et al.
Frontiers in cellular neuroscience, 7, 12-12 (2013-02-20)
Striatal functions depend on the activity balance between the dopamine and glutamate neurotransmissions. Glutamate inputs activate cyclin-dependent kinase 5 (Cdk5), which inhibits postsynaptic dopamine signaling by phosphorylating DARPP-32 (dopamine- and cAMP-regulated phosphoprotein, 32 kDa) at Thr75 in the striatum. c-Abelson
J W Kebabian et al.
American journal of hypertension, 3(6 Pt 2), 40S-42S (1990-06-01)
A68930 (5,6-dihydroxy-3-phenyl-1-aminomethyl-isochroman) is a potent (EC50 = 2.5 nmol/L) partial agonist at the D-1 dopamine receptor. In contrast, A68930 is a much weaker agonist (EC50 = 3,920 nmol/L) at the D-2 dopamine receptor. The orientation of the 3-phenyl substituent in
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