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Merck
CN

A9043

S-乙酰巯基乙酸 N-羟基琥珀酰亚胺酯

≥95% (TLC), powder

别名:

N-丁二酸S-乙酰基巯基乙二醇酯, N-琥珀酰亚胺基-S-乙酰硫基乙酸酯, S-乙酰硫基乙酸琥珀酰亚胺酯, SATA

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关于此项目

经验公式(希尔记法):
C8H9NO5S
化学文摘社编号:
分子量:
231.23
UNSPSC Code:
12352100
NACRES:
NA.22
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
7815491
Assay:
≥95% (TLC)
Form:
powder
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Quality Level

assay

≥95% (TLC)

form

powder

solubility

acetonitrile: 50 mg/mL, DMF: soluble

storage temp.

−20°C

SMILES string

CC(=O)SCC(=O)ON1C(=O)CCC1=O

InChI

1S/C8H9NO5S/c1-5(10)15-4-8(13)14-9-6(11)2-3-7(9)12/h2-4H2,1H3

InChI key

FLCQLSRLQIPNLM-UHFFFAOYSA-N

Application

伯胺的硫醇化试剂;在温和条件下可使硫醇去保护。通常在 pH 为 7.5 时引发耦合反应,通过酰胺键生成含伯胺的分子。在中性 pH 时可与 0.05M 羟胺发生去保护反应。用于制备酶免疫交联剂和半抗原载体分子偶联物。

Other Notes

注意,与其他硫醇化试剂相比,对伯胺的酯偶合作用非常有效。此外,这种试剂可以中和伯胺的正电荷。

存储类别

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)


历史批次信息供参考:

分析证书(COA)

Lot/Batch Number

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Magnus Bergkvist et al.
Methods in molecular biology (Clifton, N.J.), 751, 381-400 (2011-06-16)
Over the last decade, scanning probe microscopy (SPM) techniques, such as atomic force microscopy (AFM), have played an important role in a variety of biophysical research efforts. This straightforward technique has the capability to measure forces down to a few
Screening of monoclonal antibodies using antigens labeled with acetylcholinesterase.
Y Frobert et al.
Methods in molecular biology (Clifton, N.J.), 80, 57-68 (1998-07-17)
Yi Wang et al.
Nature protocols, 2(4), 972-978 (2007-04-21)
The mercaptoacetyltriglycine (MAG3) chelator has been shown to stably complex technetium-99m (99mTc) for nuclear imaging and radiorhenium (186/188Re) for tumor radiation therapy studies. The bifunctional N-hydroxysuccinimidyl ester of MAG3 with S-acetyl protection (N-hydroxysuccinimidyl S-acetylmercaptoacetyltriglycinate (NHS-MAG3)) has been successfully used to
M H Vingerhoeds et al.
Pharmaceutical research, 13(4), 604-610 (1996-04-01)
Immuno-enzymosomes are tumor-specific immunoliposomes bearing enzymes on their surface. These enzymes are capable of converting relatively nontoxic prodrugs into active cytostatic agents. The enzyme beta-glucuronidase (GUS)4 was coupled to the external surface of immunoliposomes directed against ovarian carcinoma cells. This
Malcolm N Jones
Methods in enzymology, 391, 211-228 (2005-02-22)
Methods are described for the preparation of anionic and cationic liposomes and proteoliposomes with covalently linked lectins or antibodies by the extrusion technique (vesicles by extrusion, VETs). The liposomes are prepared from the phospholipid dipalmitoylphosphatidylcholine (DPPC), together with the anionic

全球贸易项目编号

货号GTIN
A9043-10MG04061832421322
A9043-50MG04061832421339
A9043-100MG04061832421315

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