A9295
4-Androsten-4-ol-3,17-dione acetate
别名:
4-Acetoxy-4-androstene-3,17-dione
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关于此项目
经验公式（希尔记法）:
C21H28O4
化学文摘社编号:
分子量:
344.44
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
Form:
solid
InChI
1S/C21H28O4/c1-12(22)25-19-16-5-4-13-14-6-7-18(24)21(14,3)10-8-15(13)20(16,2)11-9-17(19)23/h13-15H,4-11H2,1-3H3/t13-,14-,15-,20+,21-/m0/s1
SMILES string
CC(=O)OC1=C2CC[C@H]3[C@@H]4CCC(=O)[C@@]4(C)CC[C@@H]3[C@@]2(C)CCC1=O
InChI key
LRXSFNGKRCOHRS-VMRCMBGLSA-N
form
solid
shipped in
ambient
storage temp.
2-8°C
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
法规信息
新产品
此项目有
Recent advances in studies on estrogen biosynthesis.
A M Brodie
Journal of endocrinological investigation, 2(4), 445-460 (1979-10-01)
A M Brodie et al.
Cancer research, 42(8 Suppl), 3360s-3364s (1982-08-01)
Aromatase inhibitor, 4-hydroxyandrostene-3,17-dione (4-OHA), is a highly effective treatment in rats with 7,12-dimethylbenz(a) anthracene-induced hormone-dependent mammary tumors. Over 90% of tumors regress to less than one-half of their original size, and a high proportion regress completely. Treatment of rats with
Effect of an aromatase inhibitor (4-acetoxy-4-androstene-3,17-dione) on the stimulatory action of luteinizing hormone on estradiol-17 beta synthesis by rat preovulatory follicles in vitro.
G Evans et al.
Biology of reproduction, 25(2), 290-294 (1981-09-01)
S A Daniel et al.
Canadian journal of physiology and pharmacology, 61(5), 507-511 (1983-05-01)
Androgens have been shown to enhance follicle-stimulating hormones (FSH) induced aromatase activity in cultured granulosa cells obtained from the ovaries of immature rats, however, aromatizable androgens are more effective than nonaromatizable androgens. The present study was designed to investigate the
A M Brodie et al.
Steroids, 38(6), 693-702 (1981-12-01)
4-Hydroxy-4-androstene-3,17-dione (4-OHA) and 4-acetoxy-4-androstene-3,17-dione (4-AcA), in addition to being competitive inhibitors of aromatase, cause time-dependent, irreversible, loss of enzyme activity in both human placental and rat ovarian microsomes. In vivo, treatment of rats with 4-OHA also causes loss of ovarian
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