登录 查看组织和合同定价。
选择尺寸
关于此项目
经验公式(希尔记法):
C10H12N5O6P
化学文摘社编号:
分子量:
329.21
NACRES:
NA.77
PubChem Substance ID:
eCl@ss:
32160414
UNSPSC Code:
41106305
EC Number:
200-492-9
MDL number:
Beilstein/REAXYS Number:
52645
产品名称
腺苷-3′,5′-环单磷酸, ≥98.5% (HPLC), powder
InChI key
IVOMOUWHDPKRLL-KQYNXXCUSA-N
InChI
1S/C10H12N5O6P/c11-8-5-9(13-2-12-8)15(3-14-5)10-6(16)7-4(20-10)1-19-22(17,18)21-7/h2-4,6-7,10,16H,1H2,(H,17,18)(H2,11,12,13)/t4-,6-,7-,10-/m1/s1
SMILES string
Nc1ncnc2n(cnc12)[C@@H]3O[C@@H]4COP(O)(=O)O[C@H]4[C@H]3O
assay
≥98.5% (HPLC)
form
powder
color
white
mp
260 °C (dec.) (lit.)
solubility
H2O: 10 mg/mL, clear, colorless (pH of aqueous solution is approx. 3.0. The sodium salt (A6885) is about 20× more soluble.)
storage temp.
−20°C
Quality Level
Gene Information
human ... OPRK1(4986)
Application
腺苷3′,5′-环一磷酸已用于:
- 在胚胎脊髓神经细胞培养中作为细胞培养基补充剂
- 作为灌注研究中林格溶液的一个组成部分
- 在人肺癌细胞系中诱导神经内分泌分化
Biochem/physiol Actions
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP 是一种重要的第二信使,并且在很多系统中与神经递质或激素诱导的受体激活相关。已有显示,cAMP/PKA 信号通路可抑制细胞增殖,诱导分化并导致细胞凋亡。
环化腺苷酸依赖性蛋白激酶 (PKA) 的自然活化剂。cAMP/PKA 信号通路可抑制细胞增殖,诱导分化并导致细胞凋亡。
Features and Benefits
该化合物是用于ADME Tox和环核苷酸研究的特色产品。发现更多精选用于 ADME Tox 和 环核苷酸 研究的产品。了解更多有关用于其他研究领域的生物活性小分子的信息,请访问 sigma.com/discover-bsm。
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Generation of human brain region-specific organoids using a miniaturized spinning bioreactor
Qian X, et al.
Nature Protocols, 13(3), 565-565 (2018)
Neuroendocrine differentiation contributes to radioresistance development and metastatic potential increase in non-small cell lung cancer
Zhu R, et al.
Biochimica et Biophysica Acta - Molecular Cell Research, 1865(12), 1878-1890 (2018)
Tissue engineering the monosynaptic circuit of the stretch reflex arc with co-culture of embryonic motoneurons and proprioceptive sensory neurons
Guo X, et al.
Biomaterials, 33(23), 5723-5731 (2012)
Linghai Yang et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(14), 4896-4904 (2014-04-04)
Striatal medium spiny neurons (MSNs) mediate many of the physiological effects of dopamine, including the regulation of feeding and motor behaviors. Dopaminergic inputs from the midbrain modulate MSN excitability through pathways that involve cAMP and protein kinase A (PKA), but
Hengxiang Cui et al.
The Journal of biological chemistry, 289(50), 34871-34885 (2014-09-14)
Angiogenesis, the formation of new blood vessels from pre-existing ones, is essential for development, wound healing, and tumor progression. The VEGF pathway plays irreplaceable roles during angiogenesis, but how other signals cross-talk with and modulate VEGF cascades is not clearly
商品
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
Discover Bioactive Small Molecules for ADME/Tox
我们的科学家团队拥有各种研究领域经验,包括生命科学、材料科学、化学合成、色谱、分析及许多其他领域.
联系客户支持