A9546
2-氨基-6-甲基巯基嘌呤
≥95%
别名:
2-氨基-6-甲基硫嘌呤
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关于此项目
经验公式（希尔记法）:
C6H7N5S
化学文摘社编号:
分子量:
181.22
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
214-833-4
MDL number:
Assay:
≥95%
Form:
solid
Quality Level
assay
≥95%
form
solid
SMILES string
[H]n1cnc2c(SC)nc(N)nc12
InChI
1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
InChI key
YEGKYFQLKYGHAR-UHFFFAOYSA-N
Application
2-氨基-6-甲基巯基嘌呤（6-MTG）已用作Dulbecco′s改良的Eagles培养基（DMEM）培养基的补充剂，用于选择表达GPT的重组病毒mCMVhMIEPE-gpt.lacZ（巨细胞病毒主要立即早期启动子-增强子复合物-gpt.lacz）。它也已用作高效液相色谱（HPLC）中的标准品，以评估巯嘌呤甲基转移酶（TPMT）酶的活性。
2-氨基-6-甲基巯基嘌呤是一种2-氨基-6-烷基二硫代嘌呤，已与其他6位碳类似物一起用于研究大脑特异性地西泮的结合。
Biochem/physiol Actions
2-氨基-6-甲基巯基嘌呤是由6-巯基嘌呤通过硫嘌呤甲基转移酶（TMPT）酶的S甲基化活性合成的。
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
存储类别
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
G R Erdmann et al.
Journal of chromatography, 571(1-2), 149-156 (1991-11-15)
A reversed-phase high-performance liquid chromatographic (HPLC) procedure was developed to quantify intracellular lymphocyte 6-thioguanine, methylmercaptopurine and methylthioguanine. The free base of each metabolite was obtained by acid hydrolysis, which allowed for a total determination of thiopurine metabolites. 6-Thioguanine was analyzed
Pharmacogenetics of drug metabolizing enzyme: thiopurine methyl transferase phenotypes and multidrug resistance 1 gene polymorphism in inflammatory bowel disease
Bahrehmand F, et al.
Cellular and Molecular Biology, 62(7), 102-109 (2016)
Cancer Chemotherapy and Biotherapy: Principles and Practice, 193-193 (2010)
全球贸易项目编号
| 货号 | GTIN |
|---|---|
| A9546-100MG | 04061833045381 |